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BioCyc to Adopt Subscription Model

April 11, 2016

BioCyc seeks the support of the scientific community as we begin a new chapter in the development of this bioinformatics resource.

Our goal is to upgrade the curation level and quality of many BioCyc databases to provide scientists with higher quality information resources for many important microbes, and for Homo sapiens. Such an effort requires large financial resources that -- despite numerous attempts over numerous years -- have not been forthcoming from government funding agencies. Thus, we plan to transition BioCyc to a community-supported non-profit subscription model in the coming months. [Note: The BioCyc subscription model began in July 2016.]

Our Goal

Our goal at BioCyc is to provide scientists with the highest quality microbial genome and metabolic pathway web portal in the world by coupling unique and high-quality database content with powerful and user-friendly bioinformatics tools. Our work on EcoCyc has demonstrated the way forward. EcoCyc is an incredibly rich and detailed information resource whose contents have been derived from 30,000 E. coli publications. EcoCyc is an online electronic encyclopedia, a highly structured queryable database, a bioinformatics platform for omics data analysis, and an executable metabolic model. EcoCyc is highly used by the life-sciences community, demonstrating the need and value of such a resource.

Our goal is to develop similar high-quality databases for other organisms. BioCyc now contains 7,600 databases, but only 42 of them have undergone any literature-based curation, and that curation occurs irregularly. Although bioinformatics algorithms have undergone amazing advances in the past two decades, their accuracy is still limited, and no bioinformatics inference algorithms exist for many types of biological information. The experimental literature contains vast troves of valuable information, and despite advances in text mining algorithms, curation by experienced biologists is the only way to accurately extract that information. EcoCyc curators extract a wide range of information on protein function; on metabolic pathways; and on regulation at the transcriptional, translational, and post-translational levels.

In the past year SRI has performed significant curation on the BioCyc databases for Saccharomyces cerevisiae, Bacillus subtilis, Mycobacterium tuberculosis, Clostridium difficile, and (to be released shortly) Corynebacterium glutamicum. All told, BioCyc databases have been curated from 66,000 publications, and constitute a unique resource in the microbial informatics landscape. Yet much more information remains untapped in the biomedical literature, and new information is published at a rapid pace. That information can be extracted only by professional curators who understand both the biology, and the methods for encoding that biology in structured databases. Without adequate financial resources, we cannot hire these curators, whose efforts are needed on an ongoing basis.

Why Do We Seek Financial Support from the Scientific Community?

The EcoCyc project has been fortunate to receive government funding for its development since 1992. Similar government-supported databases exist for a handful of biomedical model organisms, such as fly, yeast, worm, and zebrafish. Peter Karp has been advocating that the government fund similar efforts for other important microbes for the past twenty years, such as for pathogens, biotechnology workhorses, model organisms, and synthetic-biology chassis for biofuels development. He has developed the Pathway Tools software as a software platform to enable the development of curated EcoCyc-like databases for other organisms, and the software has been used by many groups. However, not only has government support for databases not kept pace with the relentless increases in experimental data generation, but the government is funding few new databases, is cutting funding for some existing databases (such as for EcoCyc, for BioCyc, and for TAIR), and is encouraging the development of other funding models for supporting databases [1]. Funding for BioCyc was cut by 27% at our last renewal whereas we are managing five times the number of genomes as five years ago. We also find that even when government agencies want to support databases, review panels score database proposals with low enthusiasm and misunderstanding, despite the obvious demand for high-quality databases by the scientific community.

Put another way: the Haemophilus influenzae genome was sequenced in 1995. Now, twenty years later, no curated database that is updated on an ongoing basis exists for this important human pathogen. Mycobacterium tuberculosis was sequenced in 1998, and now, eighteen years later, no comprehensive curated database exists for the genes, metabolism, and regulatory network of this killer of 1.5 million human beings per year. No curated database exists for the important gram-positive model organism Bacillus subtilis. How much longer shall we wait for modern resources that integrate the titanic amounts of information available about critical microbes with powerful bioinformatics tools to turbocharge life-science research?

How it Will Work and How You Can Support BioCyc

The tradition whereby scientific journals receive financial support from scientists in the form of subscriptions is a long one. We are now turning to a similar model to support the curation and operation of BioCyc. We seek individual and institutional subscriptions from those who receive the most value from BioCyc, and who are best positioned to direct its future evolution. We have developed a subscription-pricing model that is on par with journal pricing, although we find that many of our users consult BioCyc on a daily basis -- more frequently than they consult most journals. We hope that this subscription model will allow us to raise more funds, more sustainably, than is possible through government grants, through our wide user base in academic, corporate, and government institutions around the world. We will also be exploring other possible revenue sources, and additional ways of partnering with the scientific community.

BioCyc is collaborating with Phoenix Bioinformatics to develop our community-supported subscription model. Phoenix is a nonprofit that already manages community financial support for the TAIR Arabidopsis database, which was previously funded by the NSF and is now fully supported [2] by users. Phoenix Bioinformatics will collect BioCyc subscriptions on behalf of SRI International, which like Phoenix is a non-profit institution. Subscription revenues will be invested into curation, operation, and marketing of the BioCyc resource. Subscription inquiries maybe directed to .

We plan to go slow with this transition to give our users time to adapt. We’ll begin requiring subscriptions for access to BioCyc databases other than EcoCyc and MetaCyc starting in July 2016.

Access to the EcoCyc and MetaCyc databases will remain free. Subscriptions to the other 7,600 BioCyc databases will be available to institutions (e.g., libraries), and to individuals. One subscription will grant access to all of BioCyc. To encourage your institutional library to sign up, please contact your science librarian and let him or her know that continued access to BioCyc is important for your research and/or teaching.

Subscription prices will be based on website usage levels and we hope to keep them affordable so that everyone who needs these databases will still be able to access them. We are finalizing the academic library and individual prices and will follow up soon with more information including details on how to sign up. We will make provisions to ensure that underprivileged scientists and students in third-world countries aren’t locked out.

Please spread the word to your colleagues -- the more groups who subscribe, the better quality resource we can build for the scientific community.

[1] http://www.nature.com/nature/journal/v527/n7576_supp/full/527S16a.html

[2] http://database.oxfordjournals.org/content/2016/baw018.long