Holiday Shutdown &
Maintenance Outage
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Holiday Shutdown &
Maintenance Outage
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Holiday Shutdown &
Maintenance Outage
click for details
Holiday Shutdown &
Maintenance Outage
click for details
Holiday Shutdown &
Maintenance Outage
click for details

Chokepoint Reaction Finder

Include reactions found in human
Exclude reactions found in human

Include reactions catalyzed by more than one enzyme
Exclude reactions catalyzed by more than one enzyme

Include all reactions
Limit to reactions found in multiple pathways

Definition: A chokepoint reaction is a reaction that is either the unique consumer of a given metabolite (the only reaction consuming that metabolite), or is the unique producer of a metabolite. That metabolite must have at least one reaction that consumes it and at least one reaction that produces it (in other words, the metabolite must not be a dead-end). In theory, chokepoint reactions make good drug targets because disabling that reaction disrupts the only path to or from a metabolite.

The definition of a chokepoint used here was derived from: Genome Research 14:917 (2004) "Computational analysis of Plasmodium falciparum metabolism: Organizing genomic information to facilitate drug discovery". [Pubmed].

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