Hierarchical Pathway Listing for Homo sapiens

Table of Contents

• Metabolite Activation/Inactivation/Interconversion:Metabolite Activation
• Metabolite Activation/Inactivation/Interconversion:Metabolite Interconversion
• Biosynthesis:Amino Acid Biosynthesis
• Biosynthesis:Aromatic Compound Biosynthesis
• Biosynthesis:Carbohydrate Biosynthesis
• Biosynthesis:Carboxylic Acid Biosynthesis
• Biosynthesis:Cofactor, Carrier, and Vitamin Biosynthesis
• Biosynthesis:Cyclitol Biosynthesis
• Biosynthesis:Hormone, Neurotransmitter, and Signaling Molecule Biosynthesis
• Biosynthesis:Fatty Acid and Lipid Biosynthesis
• Biosynthesis:Metabolic Regulator Biosynthesis
• Biosynthesis:Nucleoside and Nucleotide Biosynthesis
• Biosynthesis:Other Biosynthesis
• Biosynthesis:Amide, Amidine, Amine, and Polyamine Biosynthesis
• Biosynthesis:Polyprenyl Biosynthesis
• Biosynthesis:Secondary Metabolite Biosynthesis
• Biosynthesis:Tetrapyrrole Biosynthesis
• Degradation/Utilization/Assimilation:Alcohol Degradation
• Degradation/Utilization/Assimilation:Aldehyde Degradation
• Degradation/Utilization/Assimilation:Amide, Amidine, Amine, and Polyamine Degradation
• Degradation/Utilization/Assimilation:Amino Acid Degradation
• Degradation/Utilization/Assimilation:Aromatic Compound Degradation
• Degradation/Utilization/Assimilation:C1 Compound Utilization and Assimilation
• Degradation/Utilization/Assimilation:Carbohydrate Degradation
• Degradation/Utilization/Assimilation:Carboxylic Acid Degradation
• Degradation/Utilization/Assimilation:Cofactor, Carrier, and Vitamin Degradation
• Degradation/Utilization/Assimilation:Cyclitol Degradation
• Degradation/Utilization/Assimilation:Fatty Acid and Lipid Degradation
• Degradation/Utilization/Assimilation:Hormone, Neurotransmitter, and Signaling Molecule Degradation
• Degradation/Utilization/Assimilation:Inorganic Nutrient Metabolism
• Degradation/Utilization/Assimilation:Nucleoside and Nucleotide Degradation
• Degradation/Utilization/Assimilation:Degradation/Utilization/Assimilation - Other
• Degradation/Utilization/Assimilation:Polymeric Compound Degradation
• Detoxification:8-oxo-GTP and 8-oxo-dGTP Detoxification
• Detoxification:Acid Resistance
• Detoxification:Arsenic Compound Detoxification
• Detoxification:Methylglyoxal Detoxification
• Detoxification:Reactive Oxygen Species Degradation
• Detoxification
• Generation of Precursor Metabolites and Energy:Acetyl-CoA Biosynthesis
• Generation of Precursor Metabolites and Energy:Electron Transfer Chains
• Generation of Precursor Metabolites and Energy:Fermentation
• Generation of Precursor Metabolites and Energy:Glycolysis
• Generation of Precursor Metabolites and Energy:Pentose Phosphate Pathways
• Generation of Precursor Metabolites and Energy:Respiration
• Generation of Precursor Metabolites and Energy:TCA cycle
• Generation of Precursor Metabolites and Energy
• Glycan Pathways:Polysaccharide Biosynthesis
• Glycan Pathways:Protein Glycosylation
• Glycan Pathways:Sphingolipid Biosynthesis
• Glycan Pathways
• Macromolecule Modification:Aminoacyl-tRNA Charging
• Macromolecule Modification:Nucleic Acid Processing
• Macromolecule Modification:Protein Modification
• Macromolecule Modification
• Metabolic Clusters
• Signal transduction pathways

Overview

This page presents some of the evidence used to determine which pathways are present in Homo sapiens. For each pathway, we show

• A diagram (the pathway evidence glyph) summarizing the presence of enzymes for each reaction in the pathway
• The normalized pathway score computed for the pathway
• The total number of reactions in the pathway
• The number of pathway reactions which an enzyme is present in Homo sapiens
• The number of those reactions that appear in other pathways in Homo sapiens (and hence are not unique to the particular pathway)
• The number of reactions designated in MetaCyc as key indicators for the presence of this pathway, for which enzymes are present in Homo sapiens
• Whether this organism is within the taxonomic groups (if any) designated in MetaCyc as the taxonomic range of this pathway

Key to Pathway Evidence Glyph Edge Colors

	Enzyme present. An enzyme for this reaction has been identified in this organism
	Enzyme absent. An enzyme for this reaction has not been identified in this organism
	Unique reaction. This reaction is unique to this pathway in the MetaCyc database
	Enzyme present by hole filler. An enzyme for this reaction has been identified in this organism by the Pathway Hole Filler
	Orphan reaction. No sequenced enzyme from any domain of life is known for this reaction
	Key reaction. The reaction has been designated a key reaction of this pathway
	Spontaneous/other. Used for spontaneous reactions, and for lines that do not denote reactions (e.g., denoting repetition in polymerization pathways)

Pathway Summary Statistics

Fraction of genes devoted to metabolism	3051 of 59059 (5%)
Base pathways	395
Total reactions in the base pathways	1862
Base pathway reactions that are pathway holes	328 (18%)
Base pathway reactions that are not pathway holes	1534 (82%)

Metabolite Activation/Inactivation/Interconversion:Metabolite Activation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
long-chain fatty acid activation		0.283	1	1	0	(none)	0 of 0	yes
sulfate activation for sulfonation		0.675	2	2	0	(none)	0 of 0	yes

Metabolite Activation/Inactivation/Interconversion:Metabolite Interconversion

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
thiamine triphosphate metabolism		0.44	2	1	0	(none)	0 of 0	yes

Biosynthesis:Amino Acid Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
diphthamide biosynthesis		0.128	3	2	0	(none)	0 of 0	NO
diphthamide biosynthesis II (eukaryotes)		0.863	4	3	0	(none)	0 of 0	yes
glycine biosynthesis		0.88	1	1	0	(none)	0 of 0	yes
glycine biosynthesis I		0.227	1	1	0	(none)	0 of 0	yes
glycine biosynthesis II		0.429	3	3	0	(none)	0 of 0	yes
hypusine biosynthesis		1.0	5	5	0	(none)	0 of 0	yes
L-alanine biosynthesis II		0.503	1	1	0	(none)	0 of 0	yes
L-alanine biosynthesis III		0.846	1	1	0	(none)	0 of 0	yes
L-arginine degradation I (arginase pathway)		1.0	3	3	0	(none)	0 of 0	yes
L-asparagine biosynthesis I		1.0	1	1	0	(none)	0 of 0	yes
L-aspartate biosynthesis		0.488	1	1	0	(none)	0 of 0	yes
L-citrulline biosynthesis		1.0	8	7	0	(none)	0 of 0	yes
L-cysteine biosynthesis III (from L-homocysteine)		0.846	2	2	0	(none)	0 of 0	yes
L-glutamate biosynthesis		0.846	1	1	1	GABA shunt I	0 of 0	yes
L-glutamine biosynthesis I		0.503	1	1	0	(none)	0 of 0	yes
L-methionine salvage from L-homocysteine		1.0	3	3	0	(none)	0 of 0	yes
L-proline biosynthesis		1.0	4	3	0	(none)	0 of 0	yes
L-selenocysteine biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
L-serine biosynthesis I		1.0	3	3	0	(none)	0 of 0	yes
L-tyrosine biosynthesis		0.846	1	1	0	(none)	0 of 0	yes
ornithine de novo biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
protein citrullination		1.0	1	1	0	(none)	0 of 0	yes
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I		1.0	7	7	0	(none)	1 of 1	yes
serine racemization		0.846	1	1	0	(none)	0 of 0	yes
uracil degradation I (reductive)		1.0	3	3	0	(none)	0 of 0	yes

Biosynthesis:Aromatic Compound Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
4-hydroxybenzoate biosynthesis		0.0925	5	1	0	(none)	0 of 0	yes

Biosynthesis:Carbohydrate Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide		1.0	10	10	0	(none)	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide		1.0	11	11	2	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
alpha-dystroglycan glycosylation		1.0	7	7	0	(none)	0 of 0	yes
chondroitin biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
chondroitin sulfate biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)		1.0	5	5	0	(none)	3 of 3	yes
complex N-linked glycan biosynthesis (vertebrates)		1.0	10	10	0	(none)	0 of 0	yes
dermatan sulfate biosynthesis		1.0	6	4	0	(none)	0 of 0	yes
erythritol biosynthesis II		0.88	2	1	0	(none)	0 of 0	yes
GDP-glucose biosynthesis II		na	3	3	0	(none)	0 of 0	yes
GDP-L-fucose biosynthesis I (from GDP-D-mannose)		1.0	3	3	0	(none)	2 of 2	yes
GDP-L-fucose biosynthesis II (from L-fucose)		1.0	2	2	0	(none)	0 of 0	yes
GDP-mannose biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
gluconeogenesis		1.0	12	12	0	(none)	0 of 0	yes
glycogen biosynthesis		1.0	4	4	0	(none)	1 of 1	yes
glycosaminoglycan-protein linkage region biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
heparan sulfate biosynthesis		1.0	12	12	0	(none)	0 of 0	yes
human milk oligisaccharides biosynthesis		1.0	19	17	0	(none)	0 of 0	yes
i antigen and I antigen biosynthesis		1.0	6	5	5	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
mucin core 1 and core 2 O-glycosylation		1.0	5	5	0	(none)	0 of 0	yes
mucin core 3 and core 4 O-glycosylation		1.0	3	3	0	(none)	0 of 0	yes
protein N-glycosylation initial phase (eukaryotic)		1.0	19	16	0	(none)	0 of 0	yes
protein N-glycosylation processing phase (mammalian)		1.0	20	19	0	(none)	0 of 0	yes
protein O-mannosylation II (mammals, core M1 and core M2)		1.0	5	4	0	(none)	0 of 0	yes
protein O-mannosylation III (mammals, core M3)		1.0	5	5	0	(none)	0 of 0	yes
protein O-[N-acetyl]-glucosylation		1.0	2	2	0	(none)	0 of 0	yes
PRPP biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
UDP-alpha-D-glucose biosynthesis		0.487	2	2	0	(none)	0 of 0	yes
UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)		0.423	1	1	0	(none)	0 of 0	yes
UDP-N-acetyl-D-galactosamine biosynthesis I		0.644	1	1	0	(none)	0 of 0	yes
UDP-N-acetyl-D-galactosamine biosynthesis II		0.535	7	7	0	(none)	1 of 1	NO
UDP-N-acetyl-D-glucosamine biosynthesis II		1.0	6	6	0	(none)	0 of 0	yes

Biosynthesis:Carboxylic Acid Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
itaconate biosynthesis I		1.0	2	1	0	(none)	1 of 1	yes

Biosynthesis:Cofactor, Carrier, and Vitamin Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
cobalamin salvage (eukaryotic)		1.0	8	7	0	(none)	0 of 0	yes
coenzyme A biosynthesis II (eukaryotic)		1.0	4	4	0	(none)	1 of 1	yes
cytochrome c biogenesis		0.846	1	1	0	(none)	0 of 0	yes
dipyrromethane cofactor biosynthesis		0.635	4	3	0	(none)	0 of 0	yes
flavin biosynthesis		0.545	2	2	0	(none)	0 of 0	yes
folate polyglutamylation		0.446	5	4	0	(none)	0 of 0	yes
folate transformations I		na	12	10	0	(none)	0 of 0	yes
heme a biosynthesis		1.0	4	3	0	(none)	2 of 2	yes
heme b biosynthesis I (aerobic)		1.0	4	4	0	(none)	1 of 1	yes
lipoate biosynthesis and incorporation V (mammals)		1.0	4	4	0	(none)	0 of 0	yes
menaquinol-4 biosynthesis II		0.587	3	1	0	(none)	0 of 0	yes
molybdenum cofactor biosynthesis		0.423	3	2	0	(none)	0 of 1	yes
molybdopterin biosynthesis		1.0	6	5	0	(none)	0 of 0	yes
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde		1.0	4	3	0	(none)	0 of 0	yes
NAD phosphorylation and transhydrogenation		0.675	2	2	0	(none)	0 of 0	yes
NAD salvage		0.421	2	2	0	(none)	1 of 1	yes
NAD salvage pathway IV (from nicotinamide riboside)		1.0	2	2	0	(none)	0 of 0	yes
NADP biosynthesis		0.503	1	1	0	(none)	0 of 0	yes
pyridoxal 5'-phosphate salvage		na	5	5	0	(none)	0 of 0	yes
retinoate biosynthesis I		1.0	4	4	0	(none)	0 of 0	yes
retinoate biosynthesis II		1.0	3	3	0	(none)	0 of 0	yes
retinol biosynthesis		1.0	7	7	0	(none)	0 of 0	yes
S-adenosyl-L-methionine biosynthesis		0.114	1	1	0	(none)	0 of 0	NO
tetrahydrobiopterin de novo biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate		0.653	2	2	0	(none)	0 of 0	yes
tetrahydropteridine recycling		1.0	2	2	0	(none)	0 of 0	yes
the visual cycle I (vertebrates)		1.0	12	8	0	(none)	0 of 0	yes
thiamine salvage III		0.128	1	1	0	(none)	0 of 0	yes
thio-molybdenum cofactor biosynthesis		0.88	1	1	0	(none)	0 of 0	yes
ubiquinol-10 biosynthesis (late decarboxylation)		1.0	10	8	0	(none)	0 of 0	yes
vitamin D3 biosynthesis		1.0	4	2	0	(none)	1 of 1	yes
vitamin K-epoxide cycle		1.0	4	4	0	(none)	0 of 0	yes
[2Fe-2S] iron-sulfur cluster biosynthesis		0.176	10	1	0	(none)	0 of 0	yes

Biosynthesis:Cyclitol Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)		1.0	5	5	0	(none)	1 of 1	yes
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)		0.843	5	5	0	(none)	1 of 1	NO
D-myo-inositol (1,3,4)-trisphosphate biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
D-myo-inositol (1,4,5)-trisphosphate biosynthesis		1.0	5	5	0	(none)	0 of 0	yes
D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis		1.0	4	4	0	(none)	1 of 1	yes
D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis		1.0	4	4	0	(none)	1 of 1	yes
D-myo-inositol-5-phosphate metabolism		1.0	4	4	0	(none)	0 of 0	yes
inositol diphosphates biosynthesis		1.0	6	6	0	(none)	0 of 0	yes
myo-inositol biosynthesis		1.0	2	2	0	(none)	1 of 1	yes

Biosynthesis:Hormone, Neurotransmitter, and Signaling Molecule Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
11-oxyandrogens biosynthesis		1.0	20	19	0	(none)	0 of 0	yes
androgen biosynthesis		1.0	6	6	0	(none)	0 of 0	yes
backdoor pathway of androgen biosynthesis		1.0	13	11	0	(none)	0 of 0	yes
C20 prostanoid biosynthesis		0.696	17	11	0	(none)	0 of 0	yes
catecholamine biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
estradiol biosynthesis I (via estrone)		1.0	4	4	0	(none)	0 of 0	yes
estradiol biosynthesis II		1.0	3	3	0	(none)	0 of 0	yes
glucocorticoid biosynthesis		1.0	4	3	0	(none)	0 of 0	yes
leukotriene biosynthesis		1.0	6	6	0	(none)	0 of 0	yes
mineralocorticoid biosynthesis		1.0	5	4	0	(none)	0 of 0	yes
pregnenolone biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
progesterone biosynthesis		0.846	2	2	0	(none)	0 of 0	yes
serotonin and melatonin biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
thyroid hormone biosynthesis		1.0	6	5	0	(none)	4 of 4	yes
vitamin D3 biosynthesis		1.0	4	2	0	(none)	1 of 1	yes

Biosynthesis:Fatty Acid and Lipid Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)		1.0	5	4	0	(none)	1 of 1	yes
3-phosphoinositide biosynthesis		1.0	8	8	0	(none)	0 of 0	yes
acyl-CoA hydrolysis		0.88	1	1	0	(none)	0 of 0	yes
acylceramide biosynthesis and processing		1.0	8	7	0	(none)	0 of 0	yes
allopregnanolone biosynthesis		1.0	2	2	0	(none)	0 of 0	yes
anandamide biosynthesis I		1.0	12	10	0	(none)	3 of 3	yes
anandamide biosynthesis II		0.872	8	5	0	(none)	0 of 0	yes
arachidonate biosynthesis V (8-detaturase, mammals)		1.0	6	4	1	arachidonate biosynthesis III (6-desaturase, mammals)	2 of 2	yes
arachidonate metabolites biosynthesis		0.551	74	34	0	(none)	0 of 0	yes
bile acid biosynthesis, neutral pathway		1.0	29	21	0	(none)	1 of 1	yes
cardiolipin biosynthesis		1.0	3	3	2	phosphatidylglycerol biosynthesis II	0 of 0	yes
CDP-diacylglycerol biosynthesis I		0.564	4	3	0	(none)	0 of 0	yes
ceramide de novo biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
D-myo-inositol-5-phosphate metabolism		1.0	4	4	0	(none)	0 of 0	yes
di-homo-gamma-linolenate metabolites biosynthesis		0.88	16	8	0	(none)	0 of 0	yes
diacylglycerol and triacylglycerol biosynthesis		0.372	7	4	0	(none)	0 of 0	yes
docosahexaenoate biosynthesis III (6-desaturase, mammals)		0.846	14	8	0	(none)	0 of 0	yes
docosahexaenoate biosynthesis IV (4-desaturase, mammals)		0.691	6	3	0	(none)	1 of 1	yes
docosahexaenoate metabolites biosynthesis		0.478	31	16	0	(none)	0 of 0	yes
dolichol and dolichyl phosphate biosynthesis		1.0	6	5	0	(none)	1 of 1	yes
epoxysqualene biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
fatty acid biosynthesis initiation (mitochondria)		0.702	4	3	0	(none)	1 of 1	yes
fatty acid biosynthesis initiation (type I)		1.0	3	3	0	(none)	0 of 0	yes
gala-series glycosphingolipids biosynthesis		1.0	5	4	0	(none)	0 of 0	yes
gamma-linolenate biosynthesis II (animals)		1.0	2	2	0	(none)	1 of 1	yes
ganglio-series glycosphingolipids biosynthesis		1.0	22	22	0	(none)	0 of 0	yes
globo-series glycosphingolipids biosynthesis		1.0	8	8	0	(none)	0 of 0	yes
icosapentaenoate biosynthesis II (6-desaturase, mammals)		0.614	7	4	0	(none)	0 of 0	yes
icosapentaenoate biosynthesis III (8-desaturase, mammals)		0.742	7	4	0	(none)	1 of 1	yes
icosapentaenoate metabolites biosynthesis		0.563	35	12	0	(none)	0 of 0	yes
lacto-series glycosphingolipids biosynthesis		1.0	7	7	0	(none)	0 of 0	yes
lanosterol biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
linoleate metabolites biosynthesis		0.312	14	3	0	(none)	0 of 0	yes
long-chain fatty acid activation		0.283	1	1	0	(none)	0 of 0	yes
myristate biosynthesis (mitochondria)		1.0	25	25	0	(none)	0 of 0	yes
neolacto-series glycosphingolipids biosynthesis		1.0	12	12	0	(none)	0 of 0	yes
oleate biosynthesis		1.0	2	2	0	(none)	0 of 0	yes
palmitate biosynthesis I (type I fatty acid synthase)		1.0	31	2	0	(none)	0 of 0	yes
palmitoleate biosynthesis IV (fungi and animals)		0.652	2	2	0	(none)	0 of 0	yes
phosphatidylcholine biosynthesis I		1.0	3	3	0	(none)	0 of 0	yes
phosphatidylcholine biosynthesis V		1.0	3	3	0	(none)	0 of 0	yes
phosphatidylethanolamine biosynthesis II		0.475	4	3	0	(none)	1 of 1	yes
phosphatidylethanolamine biosynthesis III		0.846	1	1	0	(none)	0 of 0	yes
phosphatidylinositol biosynthesis II (eukaryotes)		0.644	1	1	0	(none)	0 of 0	yes
phosphatidylserine biosynthesis I		1.0	1	1	0	(none)	0 of 0	yes
phosphatidylserine biosynthesis II		0.846	1	1	0	(none)	0 of 0	yes
plasmalogen biosynthesis		1.0	16	15	0	(none)	1 of 1	yes
representative whole plasma arachidonate-derived icosanoids II		0.593	19	10	0	(none)	0 of 0	yes
representative whole plasma DHA-derived icosanoids		0.613	12	3	0	(none)	0 of 0	yes
representative whole plasma EPA-derived icosanoids		0.587	4	1	0	(none)	0 of 0	yes
sphingomyelin metabolism		1.0	3	3	3	sphingolipid biosynthesis (mammals)	0 of 0	yes
stearate biosynthesis		1.0	6	5	0	(none)	1 of 1	yes
ultra-long-chain fatty acid biosynthesis		1.0	20	20	0	(none)	0 of 0	yes
very long chain fatty acid biosynthesis II		1.0	16	14	0	(none)	0 of 0	yes
zymosterol biosynthesis		1.0	8	8	5	cholesterol biosynthesis I	0 of 0	yes

Biosynthesis:Metabolic Regulator Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
carnosine biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
creatine-phosphate biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
fructose 2,6-bisphosphate biosynthesis		1.0	2	2	0	(none)	0 of 0	yes
homocarnosine biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
L-carnitine biosynthesis		1.0	4	4	0	(none)	1 of 1	yes
nitric oxide biosynthesis II (mammals)		1.0	3	3	0	(none)	0 of 0	yes
Rapoport-Luebering glycolytic shunt		1.0	3	3	0	(none)	0 of 0	yes

Biosynthesis:Nucleoside and Nucleotide Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
5-aminoimidazole ribonucleotide biosynthesis I		1.0	5	5	0	(none)	0 of 0	yes
adenine and adenosine salvage I		0.526	2	2	0	(none)	0 of 0	yes
adenine and adenosine salvage III		1.0	4	4	0	(none)	2 of 2	yes
adenine and adenosine salvage VI		1.0	1	1	0	(none)	0 of 0	yes
adenosine deoxyribonucleotides de novo biosynthesis I		0.745	2	2	0	(none)	0 of 0	yes
adenosine ribonucleotides de novo biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
CMP phosphorylation		1.0	2	2	0	(none)	0 of 0	yes
dTMP de novo biosynthesis (mitochondrial)		1.0	3	3	0	(none)	0 of 0	yes
guanine and guanosine salvage I		0.686	2	2	0	(none)	0 of 0	yes
guanosine deoxyribonucleotides de novo biosynthesis I		0.745	2	2	0	(none)	0 of 0	yes
guanosine ribonucleotides de novo biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
inosine-5'-phosphate biosynthesis II		1.0	5	5	0	(none)	1 of 1	yes
purine deoxyribonucleosides salvage		1.0	6	6	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleosides salvage		1.0	5	5	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotide phosphorylation		1.0	4	4	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotides biosynthesis from CTP		1.0	8	8	0	(none)	1 of 1	yes
pyrimidine deoxyribonucleotides de novo biosynthesis I		1.0	9	9	0	(none)	1 of 1	yes
pyrimidine ribonucleosides salvage I		1.0	3	3	0	(none)	1 of 1	yes
UMP biosynthesis I		1.0	6	6	0	(none)	1 of 1	yes
UTP and CTP de novo biosynthesis		1.0	3	3	0	(none)	0 of 0	yes

Biosynthesis:Other Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ascorbate recycling (cytosolic)		0	6	1	0	(none)	1 of 2	yes
creatine biosynthesis		1.0	2	2	0	(none)	2 of 2	yes
glutathione biosynthesis		1.0	2	2	0	(none)	0 of 0	yes
glutathione-glutaredoxin redox reactions		0.846	2	1	0	(none)	0 of 0	yes
glutathione-peroxide redox reactions		1.0	3	3	1	reactive oxygen species degradation	0 of 0	yes
L-dopa and L-dopachrome biosynthesis		0.846	3	1	0	(none)	0 of 0	yes
ophthalmate biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
thioredoxin pathway (NADPH)		0.44	2	1	0	(none)	0 of 0	yes

Biosynthesis:Amide, Amidine, Amine, and Polyamine Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
creatine-phosphate biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
histamine biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
putrescine biosynthesis I		0.667	2	2	0	(none)	0 of 0	yes
putrescine biosynthesis III		0.667	2	2	0	(none)	0 of 0	yes
spermidine biosynthesis I		1.0	2	2	0	(none)	0 of 0	yes
spermine biosynthesis		1.0	2	2	0	(none)	1 of 1	yes
trimethylamine N-oxide biosynthesis		0.846	1	1	0	(none)	0 of 0	yes

Biosynthesis:Polyprenyl Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
geranylgeranyl diphosphate biosynthesis		0.478	1	1	0	(none)	0 of 0	yes
trans, trans-farnesyl diphosphate biosynthesis		0.791	2	2	0	(none)	1 of 1	yes

Biosynthesis:Secondary Metabolite Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
(S)-reticuline biosynthesis		0.0807	7	1	0	(none)	0 of 0	yes
2-arachidonoylglycerol biosynthesis		1.0	7	6	0	(none)	0 of 0	yes
15-epi-lipoxin biosynthesis		1.0	5	3	0	(none)	0 of 0	yes
aspirin triggered resolvin D biosynthesis		0.606	10	5	0	(none)	0 of 0	yes
aspirin triggered resolvin E biosynthesis		0.677	6	4	0	(none)	0 of 0	yes
epoxysqualene biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
eumelanin biosynthesis		1.0	6	3	0	(none)	0 of 0	yes
lipoxin biosynthesis		0.639	11	8	0	(none)	0 of 0	yes
maresin biosynthesis		0.61	5	3	0	(none)	0 of 0	yes
mevalonate pathway I (eukaryotes and bacteria)		1.0	7	7	0	(none)	2 of 2	yes
palmitoyl ethanolamide biosynthesis		1.0	6	3	0	(none)	1 of 1	yes
peptido-conjugates in tissue regeneration biosynthesis		1.0	17	16	0	(none)	0 of 0	yes
pheomelanin biosynthesis		0.423	8	1	0	(none)	0 of 0	yes
protectin biosynthesis		0.484	6	4	0	(none)	0 of 0	yes
resolvin D biosynthesis		0.624	11	7	0	(none)	0 of 0	yes
S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis		1.0	2	2	0	(none)	0 of 0	yes
taurine biosynthesis I		1.0	3	3	0	(none)	0 of 0	yes
taurine biosynthesis II		0.863	4	3	0	(none)	0 of 0	yes

Biosynthesis:Tetrapyrrole Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
cytochrome c biogenesis		0.846	1	1	0	(none)	0 of 0	yes
heme a biosynthesis		1.0	4	3	0	(none)	2 of 2	yes
heme b biosynthesis I (aerobic)		1.0	4	4	0	(none)	1 of 1	yes
uroporphyrinogen-III II (from glycine)		1.0	4	4	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Alcohol Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ethanol degradation II		1.0	3	3	0	(none)	1 of 1	yes
ethanol degradation III		1.0	3	3	0	(none)	1 of 1	yes
ethanol degradation IV		1.0	3	3	0	(none)	1 of 1	yes
glycerol degradation I		0.128	3	3	0	(none)	0 of 0	yes
mannitol degradation II		0.742	4	3	0	(none)	0 of 0	NO
phytol degradation		1.0	4	2	0	(none)	1 of 1	yes
sorbitol degradation I		0.2	3	2	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Aldehyde Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
methylglyoxal degradation I		0.0142	3	2	0	(none)	1 of 2	yes
methylglyoxal degradation III		0.423	2	1	0	(none)	0 of 0	yes
methylglyoxal degradation VI		0.652	4	1	0	(none)	0 of 0	yes
methylglyoxal degradation VIII		1.0	3	3	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:Amide, Amidine, Amine, and Polyamine Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
4-aminobutanoate degradation I		0.585	2	2	2	GABA shunt I	0 of 0	yes
choline degradation I		0.706	2	2	0	(none)	0 of 0	yes
dopamine degradation		1.0	5	5	0	(none)	0 of 0	yes
glycine betaine degradation II (mammalian)		1.0	4	4	0	(none)	0 of 0	yes
histamine degradation		1.0	3	2	0	(none)	1 of 1	yes
N-acetylglucosamine degradation I		0.302	2	2	0	(none)	0 of 0	yes
phenylethylamine degradation I		0.424	2	2	0	(none)	1 of 1	yes
putrescine degradation III		1.0	4	3	0	(none)	0 of 0	yes
spermine and spermidine degradation I		1.0	5	5	0	(none)	2 of 2	yes

Degradation/Utilization/Assimilation:Amino Acid Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
beta-alanine degradation		0.353	2	2	0	(none)	0 of 0	yes
creatine biosynthesis		1.0	2	2	0	(none)	2 of 2	yes
glycine cleavage		0.613	3	3	0	(none)	1 of 1	yes
L-alanine degradation		0.503	1	1	0	(none)	0 of 0	yes
L-arginine degradation I (arginase pathway)		1.0	3	3	0	(none)	0 of 0	yes
L-asparagine degradation I		0.88	1	1	0	(none)	0 of 0	yes
L-aspartate degradation I		0.244	1	1	0	(none)	0 of 0	yes
L-citrulline degradation		0.259	3	2	0	(none)	1 of 1	yes
L-cysteine biosynthesis III (from L-homocysteine)		0.846	2	2	0	(none)	0 of 0	yes
L-cysteine degradation I		0.652	3	2	0	(none)	0 of 0	yes
L-cysteine degradation III		1.0	2	2	0	(none)	0 of 0	yes
L-cysteine degradation IV		0.846	1	1	0	(none)	0 of 0	yes
L-dopa degradation		0.165	4	1	0	(none)	1 of 2	yes
L-glutamate degradation (via 4-aminobutanoate)		0.846	1	1	1	GABA shunt I	0 of 0	yes
L-glutamine degradation		0.455	1	1	0	(none)	0 of 0	yes
L-histidine degradation		1.0	6	6	0	(none)	0 of 0	yes
L-isoleucine degradation		1.0	6	6	0	(none)	0 of 0	yes
L-leucine degradation		1.0	6	6	0	(none)	1 of 1	yes
L-lysine degradation (pipecolate pathway)		1.0	9	7	0	(none)	0 of 0	yes
L-lysine degradation (saccharopine pathway)		1.0	5	5	0	(none)	0 of 0	yes
L-methionine degradation I (to L-homocysteine)		0.45	3	2	0	(none)	0 of 0	yes
L-phenylalanine degradation I (aerobic)		0.846	1	1	0	(none)	0 of 0	yes
L-proline degradation		0.879	3	2	0	(none)	1 of 1	yes
L-serine degradation		0.526	3	2	0	(none)	0 of 0	yes
L-threonine degradation		1.0	2	2	1	2-oxobutanoate degradation I	0 of 0	yes
L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde		1.0	5	5	0	(none)	0 of 0	yes
L-tryptophan degradation via tryptamine		1.0	4	4	0	(none)	3 of 3	yes
L-tyrosine degradation		1.0	5	5	0	(none)	0 of 0	yes
L-valine degradation		1.0	8	8	0	(none)	0 of 0	yes
trans-4-hydroxy-L-proline degradation		1.0	5	4	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Aromatic Compound Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
phenylethylamine degradation I		0.424	2	2	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:C1 Compound Utilization and Assimilation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
formaldehyde oxidation II (glutathione-dependent)		1.0	3	2	0	(none)	1 of 1	yes
formaldehyde oxidation VII (THF pathway)		0.398	4	3	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Carbohydrate Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-deoxy-alpha-D-ribose 1-phosphate degradation		0.812	3	3	0	(none)	0 of 0	yes
chondroitin sulfate degradation (metazoa)		1.0	1	1	0	(none)	0 of 0	yes
D-galactose degradation V (Leloir pathway)		na	5	5	0	(none)	0 of 0	yes
D-glucuronate degradation		0.813	5	4	0	(none)	0 of 0	yes
D-mannose degradation		na	1	1	0	(none)	0 of 0	yes
D-mannose degradation II		0.518	2	2	0	(none)	0 of 0	yes
glycerol degradation I		0.128	3	3	0	(none)	0 of 0	yes
glycogen degradation II		1.0	6	5	0	(none)	0 of 0	yes
lactose degradation III		0.4	1	1	0	(none)	0 of 0	yes
mannitol degradation II		0.742	4	3	0	(none)	0 of 0	NO
N-acetylglucosamine degradation I		0.302	2	2	0	(none)	0 of 0	yes
sorbitol degradation I		0.2	3	2	0	(none)	0 of 0	yes
sucrose degradation		1.0	5	5	0	(none)	0 of 0	yes
trehalose degradation II (cytosolic)		0.21	2	2	0	(none)	1 of 1	NO

Degradation/Utilization/Assimilation:Carboxylic Acid Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA		0.427	5	3	0	(none)	0 of 0	yes
acetate conversion to acetyl-CoA		0.478	1	1	0	(none)	0 of 0	yes
D-glucuronate degradation		0.813	5	4	0	(none)	0 of 0	yes
glutaryl-CoA degradation		1.0	5	5	0	(none)	0 of 0	yes
L-malate degradation II		0.263	1	1	0	(none)	0 of 0	yes
propanoyl CoA degradation I		1.0	3	3	0	(none)	0 of 0	yes
pyruvate decarboxylation to acetyl CoA I		1.0	3	3	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:Cofactor, Carrier, and Vitamin Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
alpha-tocopherol degradation		0.953	3	1	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:Cyclitol Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
D-myo-inositol (1,4,5)-trisphosphate degradation		1.0	3	3	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Fatty Acid and Lipid Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-methyl-branched fatty acid beta-oxidation		1.0	14	5	0	(none)	0 of 0	yes
3-phosphoinositide degradation		1.0	9	8	0	(none)	0 of 0	yes
anandamide degradation		1.0	1	1	0	(none)	0 of 0	yes
anandamide lipoxygenation		1.0	6	3	0	(none)	0 of 0	yes
fatty acid alpha-oxidation		1.0	6	5	0	(none)	2 of 2	yes
fatty acid alpha-oxidation III		1.0	7	5	0	(none)	1 of 1	yes
fatty acid beta-oxidation		0.455	7	5	0	(none)	0 of 0	yes
fatty acid beta-oxidation (peroxisome)		1.0	7	7	0	(none)	1 of 1	yes
fatty acid beta-oxidation (unsaturated, odd number)		0.846	1	1	0	(none)	0 of 0	yes
mitochondrial L-carnitine shuttle		1.0	3	3	0	(none)	1 of 1	yes
phospholipases		1.0	5	5	0	(none)	0 of 0	yes
plasmalogen degradation		1.0	8	8	0	(none)	0 of 0	yes
sphingosine and sphingosine-1-phosphate metabolism		0.841	10	5	0	(none)	0 of 0	yes
triacylglycerol degradation		1.0	3	3	0	(none)	1 of 1	yes
valproate beta-oxidation		0.876	9	5	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Hormone, Neurotransmitter, and Signaling Molecule Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
melatonin degradation I		1.0	5	5	0	(none)	2 of 2	yes
melatonin degradation II		0	4	1	0	(none)	0 of 1	yes
melatonin degradation III		0.88	2	1	0	(none)	0 of 0	yes
noradrenaline and adrenaline degradation		1.0	13	13	0	(none)	4 of 4	yes
serotonin degradation		1.0	7	6	0	(none)	1 of 1	yes
thyroid hormone metabolism I (via deiodination)		1.0	12	9	0	(none)	2 of 2	yes
thyroid hormone metabolism II (via conjugation and/or degradation)		1.0	14	10	0	(none)	6 of 6	yes
thyronamine and iodothyronamine metabolism		1.0	12	8	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Inorganic Nutrient Metabolism

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
hydrogen sulfide biosynthesis II (mammalian)		1.0	6	6	0	(none)	0 of 0	yes
L-cysteine degradation III		1.0	2	2	0	(none)	0 of 0	yes
L-glutamine biosynthesis I		0.503	1	1	0	(none)	0 of 0	yes
sulfate activation for sulfonation		0.675	2	2	0	(none)	0 of 0	yes
sulfide oxidation IV (metazoa)		1.0	5	4	0	(none)	0 of 0	yes
sulfite oxidation IV (sulfite oxidase)		0.846	1	1	0	(none)	0 of 0	yes
thiosulfate disproportionation IV (rhodanese)		0.88	1	1	0	(none)	0 of 0	yes
urea cycle		1.0	5	5	0	(none)	2 of 2	yes

Degradation/Utilization/Assimilation:Nucleoside and Nucleotide Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
adenosine nucleotides degradation II		1.0	5	5	0	(none)	1 of 1	yes
guanosine nucleotides degradation III		1.0	4	4	0	(none)	0 of 0	yes
inosine 5'-phosphate degradation		1.0	4	4	0	(none)	0 of 0	yes
purine deoxyribonucleosides degradation		1.0	3	3	0	(none)	0 of 0	yes
purine ribonucleosides degradation to ribose-1-phosphate		1.0	6	6	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleosides degradation		1.0	3	3	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotides dephosphorylation		0.388	3	2	0	(none)	0 of 0	yes
pyrimidine ribonucleosides degradation		1.0	2	2	0	(none)	1 of 1	yes
S-methyl-5'-thioadenosine degradation II		0.846	1	1	0	(none)	0 of 0	yes
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I		1.0	7	7	0	(none)	1 of 1	yes
thymine degradation		1.0	3	3	0	(none)	0 of 0	yes
uracil degradation I (reductive)		1.0	3	3	0	(none)	0 of 0	yes
UTP and CTP dephosphorylation I		1.0	7	7	0	(none)	0 of 0	yes
UTP and CTP dephosphorylation II		1.0	3	3	0	(none)	2 of 2	yes

Degradation/Utilization/Assimilation:Degradation/Utilization/Assimilation - Other

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
acetone degradation I (to methylglyoxal)		0.423	3	1	0	(none)	0 of 0	yes
acetone degradation III (to propane-1,2-diol)		0.423	2	1	0	(none)	0 of 0	yes
bupropion degradation		0.352	5	1	0	(none)	0 of 0	yes
carbon disulfide oxidation III (metazoa)		0.587	5	1	0	(none)	0 of 0	yes
glutathione-mediated detoxification I		1.0	8	6	0	(none)	0 of 0	yes
heme degradation I		1.0	6	6	0	(none)	0 of 0	yes
nicotine degradation IV		0.436	16	5	0	(none)	0 of 0	yes
nicotine degradation V		0.681	18	8	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Polymeric Compound Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
chondroitin sulfate degradation (metazoa)		1.0	1	1	0	(none)	0 of 0	yes
glycogen degradation II		1.0	6	5	0	(none)	0 of 0	yes

Detoxification:8-oxo-GTP and 8-oxo-dGTP Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
oxidized GTP and dGTP detoxification		0.88	4	1	0	(none)	0 of 0	yes

Detoxification:Acid Resistance

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
L-glutamate degradation (via 4-aminobutanoate)		0.846	1	1	1	GABA shunt I	0 of 0	yes

Detoxification:Arsenic Compound Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
arsenic detoxification (mammals)		0.647	17	8	0	(none)	1 of 3	yes

Detoxification:Methylglyoxal Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
methylglyoxal degradation I		0.0142	3	2	0	(none)	1 of 2	yes
methylglyoxal degradation III		0.423	2	1	0	(none)	0 of 0	yes
methylglyoxal degradation VI		0.652	4	1	0	(none)	0 of 0	yes
methylglyoxal degradation VIII		1.0	3	3	0	(none)	1 of 1	yes

Detoxification:Reactive Oxygen Species Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
superoxide radicals degradation		0.423	2	2	2	reactive oxygen species degradation	0 of 0	yes

Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
4-hydroxy-2-nonenal detoxification		1.0	4	3	0	(none)	0 of 0	yes
glutathione-mediated detoxification I		1.0	8	6	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Acetyl-CoA Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
acetyl-CoA biosynthesis from citrate		0.846	1	1	0	(none)	0 of 0	yes
ketolysis		1.0	3	3	0	(none)	0 of 0	yes
pyruvate decarboxylation to acetyl CoA I		1.0	3	3	0	(none)	1 of 1	yes

Generation of Precursor Metabolites and Energy:Electron Transfer Chains

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
aerobic respiration I (cytochrome c)		1.0	4	4	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Fermentation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
pyruvate fermentation to (S)-lactate		0.283	1	1	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Glycolysis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
glycolysis		na	10	10	0	(none)	0 of 0	yes
glycolysis VI (from fructose)		1.0	11	10	0	(none)	1 of 1	yes

Generation of Precursor Metabolites and Energy:Pentose Phosphate Pathways

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
pentose phosphate pathway (non-oxidative branch) I		1.0	5	5	0	(none)	1 of 1	yes
pentose phosphate pathway (oxidative branch) I		1.0	3	3	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Respiration

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-oxoisovalerate decarboxylation to isobutanoyl-CoA		1.0	3	3	0	(none)	1 of 1	yes
aerobic respiration I (cytochrome c)		1.0	4	4	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:TCA cycle

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
TCA cycle		1.0	10	10	0	(none)	2 of 2	yes

Generation of Precursor Metabolites and Energy

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-oxoglutarate decarboxylation to succinyl-CoA		1.0	3	3	0	(none)	1 of 1	yes
ATP biosynthesis		1.0	1	1	0	(none)	0 of 0	yes
glycerol-3-phosphate shuttle		0.423	2	2	0	(none)	0 of 0	yes
ketogenesis		1.0	5	5	0	(none)	0 of 0	yes
malate-aspartate shuttle		0.469	2	2	0	(none)	0 of 0	yes
malonyl-CoA biosynthesis via biotin-carboxyl carrier protein		1.0	4	3	0	(none)	0 of 0	yes
NADH repair		1.0	4	4	0	(none)	1 of 1	yes
NADPH repair (eukaryotes)		1.0	4	1	0	(none)	1 of 1	yes

Glycan Pathways:Polysaccharide Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
chondroitin biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
chondroitin sulfate biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
dermatan sulfate biosynthesis		1.0	6	4	0	(none)	0 of 0	yes
glycogen biosynthesis		1.0	4	4	0	(none)	1 of 1	yes
heparan sulfate biosynthesis		1.0	12	12	0	(none)	0 of 0	yes

Glycan Pathways:Protein Glycosylation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide		1.0	10	10	0	(none)	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide		1.0	11	11	2	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
alpha-dystroglycan glycosylation		1.0	7	7	0	(none)	0 of 0	yes
complex N-linked glycan biosynthesis (vertebrates)		1.0	10	10	0	(none)	0 of 0	yes
glycosaminoglycan-protein linkage region biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
i antigen and I antigen biosynthesis		1.0	6	5	5	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
mucin core 1 and core 2 O-glycosylation		1.0	5	5	0	(none)	0 of 0	yes
mucin core 3 and core 4 O-glycosylation		1.0	3	3	0	(none)	0 of 0	yes
protein N-glycosylation initial phase (eukaryotic)		1.0	19	16	0	(none)	0 of 0	yes
protein N-glycosylation processing phase (mammalian)		1.0	20	19	0	(none)	0 of 0	yes
protein O-mannosylation II (mammals, core M1 and core M2)		1.0	5	4	0	(none)	0 of 0	yes
protein O-mannosylation III (mammals, core M3)		1.0	5	5	0	(none)	0 of 0	yes
protein O-[N-acetyl]-glucosylation		1.0	2	2	0	(none)	0 of 0	yes

Glycan Pathways:Sphingolipid Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
acylceramide biosynthesis and processing		1.0	8	7	0	(none)	0 of 0	yes
ceramide de novo biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
gala-series glycosphingolipids biosynthesis		1.0	5	4	0	(none)	0 of 0	yes
ganglio-series glycosphingolipids biosynthesis		1.0	22	22	0	(none)	0 of 0	yes
globo-series glycosphingolipids biosynthesis		1.0	8	8	0	(none)	0 of 0	yes
lacto-series glycosphingolipids biosynthesis		1.0	7	7	0	(none)	0 of 0	yes
neolacto-series glycosphingolipids biosynthesis		1.0	12	12	0	(none)	0 of 0	yes

Glycan Pathways

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
chondroitin sulfate degradation (metazoa)		1.0	1	1	0	(none)	0 of 0	yes
glycogen degradation II		1.0	6	5	0	(none)	0 of 0	yes
human milk oligisaccharides biosynthesis		1.0	19	17	0	(none)	0 of 0	yes

Macromolecule Modification:Aminoacyl-tRNA Charging

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
glutaminyl-tRNAgln biosynthesis via transamidation		1.0	4	4	0	(none)	0 of 0	yes
tRNA charging		1.0	21	20	0	(none)	0 of 0	yes

Macromolecule Modification:Nucleic Acid Processing

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
7-(3-amino-3-carboxypropyl)-wyosine biosynthesis		0.996	4	4	0	(none)	0 of 0	NO
mRNA capping I		1.0	3	3	0	(none)	0 of 0	yes
N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis		1.0	3	3	0	(none)	0 of 0	yes
queuosine biosynthesis II (queuine salvage)		1.0	1	1	0	(none)	0 of 0	yes
tRNA splicing II		1.0	2	2	0	(none)	1 of 1	yes
tRNA-uridine 2-thiolation (cytoplasmic)		1.0	8	8	0	(none)	0 of 0	yes
tRNA-uridine 2-thiolation (mammalian mitochondria)		1.0	4	4	0	(none)	0 of 0	yes

Macromolecule Modification:Protein Modification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
5-oxo-L-proline metabolism		1.0	6	4	1	γ-glutamyl cycle	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide		1.0	10	10	0	(none)	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide		1.0	11	11	2	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
Ac/N-end rule pathway		0.791	21	21	0	(none)	0 of 0	yes
acyl carrier protein activation		0.846	1	1	0	(none)	0 of 0	yes
alpha-dystroglycan glycosylation		1.0	7	7	0	(none)	0 of 0	yes
Arg/N-end rule pathway (eukaryotic)		1.0	14	11	0	(none)	0 of 0	yes
blood coagulation - tissue factor pathway		1.0	11	8	0	(none)	0 of 0	yes
complex N-linked glycan biosynthesis (vertebrates)		1.0	10	10	0	(none)	0 of 0	yes
cytochrome c biogenesis		0.846	1	1	0	(none)	0 of 0	yes
glycosaminoglycan-protein linkage region biosynthesis		1.0	4	4	0	(none)	0 of 0	yes
glycosylphosphatidylinositol anchor biosynthesis (mammalia)		na	15	13	0	(none)	0 of 0	yes
glycosylphosphatidylinositol anchor modification (mammalia)		na	6	5	0	(none)	0 of 0	yes
i antigen and I antigen biosynthesis		1.0	6	5	5	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
mucin core 1 and core 2 O-glycosylation		1.0	5	5	0	(none)	0 of 0	yes
mucin core 3 and core 4 O-glycosylation		1.0	3	3	0	(none)	0 of 0	yes
procollagen hydroxylation and glycosylation		1.0	6	5	0	(none)	0 of 0	yes
protein N-glycosylation initial phase (eukaryotic)		1.0	19	16	0	(none)	0 of 0	yes
protein N-glycosylation processing phase (mammalian)		1.0	20	19	0	(none)	0 of 0	yes
protein NEDDylation		1.0	3	3	0	(none)	0 of 0	yes
protein O-mannosylation II (mammals, core M1 and core M2)		1.0	5	4	0	(none)	0 of 0	yes
protein O-mannosylation III (mammals, core M3)		1.0	5	5	0	(none)	0 of 0	yes
protein O-[N-acetyl]-glucosylation		1.0	2	2	0	(none)	0 of 0	yes
protein S-nitrosylation and denitrosylation		0.587	5	1	0	(none)	0 of 0	yes
protein ubiquitination		1.0	9	9	0	(none)	0 of 0	yes

Macromolecule Modification

Pathway

Pathway Glyph

Pathway Score

Total Rxns

Rxns Present in Homo sapiens

Rxns Present in Other Pwys

Other Pwys

Key Rxns Present

In Taxonomic Range?

Links

Metabolic Clusters

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-methyl-branched fatty acid beta-oxidation		1.0	14	5	0	(none)	0 of 0	yes
Ac/N-end rule pathway		0.791	21	21	0	(none)	0 of 0	yes
Arg/N-end rule pathway (eukaryotic)		1.0	14	11	0	(none)	0 of 0	yes
blood coagulation - tissue factor pathway		1.0	11	8	0	(none)	0 of 0	yes
hydrogen sulfide biosynthesis II (mammalian)		1.0	6	6	0	(none)	0 of 0	yes
oxidized GTP and dGTP detoxification		0.88	4	1	0	(none)	0 of 0	yes
phospholipases		1.0	5	5	0	(none)	0 of 0	yes
purine deoxyribonucleosides salvage		1.0	6	6	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotide phosphorylation		1.0	4	4	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotides biosynthesis from CTP		1.0	8	8	0	(none)	1 of 1	yes
pyrimidine deoxyribonucleotides de novo biosynthesis I		1.0	9	9	0	(none)	1 of 1	yes
pyrimidine deoxyribonucleotides dephosphorylation		0.388	3	2	0	(none)	0 of 0	yes
tRNA charging		1.0	21	20	0	(none)	0 of 0	yes

Signal transduction pathways

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
BMP Signalling Pathway		na	17	2	0	(none)	0 of 0	yes
MAP kinase cascade		na	4	2	0	(none)	0 of 0	yes

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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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