Hierarchical Pathway Listing for Homo sapiens

Table of Contents

• Metabolite Activation/Inactivation/Interconversion:Metabolite Activation
• Biosynthesis:Amino Acid Biosynthesis
• Biosynthesis:Aminoacyl-tRNA Charging
• Biosynthesis:Aromatic Compound Biosynthesis
• Biosynthesis:Carbohydrate Biosynthesis
• Biosynthesis:Carboxylic Acid Biosynthesis
• Biosynthesis:Cofactor, Carrier, and Vitamin Biosynthesis
• Biosynthesis:Cyclitol Biosynthesis
• Biosynthesis:Hormone, Neurotransmitter, and Signaling Molecule Biosynthesis
• Biosynthesis:Fatty Acid and Lipid Biosynthesis
• Biosynthesis:Metabolic Regulator Biosynthesis
• Biosynthesis:Nucleoside and Nucleotide Biosynthesis
• Biosynthesis:Other Biosynthesis
• Biosynthesis:Amide, Amidine, Amine, and Polyamine Biosynthesis
• Biosynthesis:Polyprenyl Biosynthesis
• Biosynthesis:Secondary Metabolite Biosynthesis
• Biosynthesis:Tetrapyrrole Biosynthesis
• Degradation/Utilization/Assimilation:Alcohol Degradation
• Degradation/Utilization/Assimilation:Aldehyde Degradation
• Degradation/Utilization/Assimilation:Amide, Amidine, Amine, and Polyamine Degradation
• Degradation/Utilization/Assimilation:Amino Acid Degradation
• Degradation/Utilization/Assimilation:Aromatic Compound Degradation
• Degradation/Utilization/Assimilation:C1 Compound Utilization and Assimilation
• Degradation/Utilization/Assimilation:Carbohydrate Degradation
• Degradation/Utilization/Assimilation:Carboxylic Acid Degradation
• Degradation/Utilization/Assimilation:Cofactor, Carrier, and Vitamin Degradation
• Degradation/Utilization/Assimilation:Cyclitol Degradation
• Degradation/Utilization/Assimilation:Fatty Acid and Lipid Degradation
• Degradation/Utilization/Assimilation:Hormone, Neurotransmitter, and Signaling Molecule Degradation
• Degradation/Utilization/Assimilation:Inorganic Nutrient Metabolism
• Degradation/Utilization/Assimilation:Nucleoside and Nucleotide Degradation
• Degradation/Utilization/Assimilation:Degradation/Utilization/Assimilation - Other
• Degradation/Utilization/Assimilation:Polymeric Compound Degradation
• Detoxification:8-oxo-GTP and 8-oxo-dGTP Detoxification
• Detoxification:Acid Resistance
• Detoxification:Arsenic Compound Detoxification
• Detoxification:Methylglyoxal Detoxification
• Detoxification:Reactive Oxygen Species Degradation
• Detoxification
• Generation of Precursor Metabolites and Energy:Acetyl-CoA Biosynthesis
• Generation of Precursor Metabolites and Energy:Electron Transfer Chains
• Generation of Precursor Metabolites and Energy:Fermentation
• Generation of Precursor Metabolites and Energy:Glycolysis
• Generation of Precursor Metabolites and Energy:Pentose Phosphate Pathways
• Generation of Precursor Metabolites and Energy:Respiration
• Generation of Precursor Metabolites and Energy:TCA cycle
• Generation of Precursor Metabolites and Energy
• Glycan Pathways:Polysaccharide Biosynthesis
• Glycan Pathways:Protein Glycosylation
• Glycan Pathways
• Macromolecule Modification:Nucleic Acid Processing
• Macromolecule Modification:Protein Modification
• Macromolecule Modification
• Metabolic Clusters
• Signal transduction pathways

Overview

This page presents some of the evidence used to determine which pathways are present in Homo sapiens. For each pathway, we show

• A diagram (the pathway evidence glyph) summarizing the presence of enzymes for each reaction in the pathway
• The normalized pathway score computed for the pathway
• The total number of reactions in the pathway
• The number of pathway reactions which an enzyme is present in Homo sapiens
• The number of those reactions that appear in other pathways in Homo sapiens (and hence are not unique to the particular pathway)
• The number of reactions designated in MetaCyc as key indicators for the presence of this pathway, for which enzymes are present in Homo sapiens
• Whether this organism is within the taxonomic groups (if any) designated in MetaCyc as the taxonomic range of this pathway

Key to Pathway Evidence Glyph Edge Colors

	Enzyme present. An enzyme for this reaction has been identified in this organism
	Enzyme absent. An enzyme for this reaction has not been identified in this organism
	Unique reaction. This reaction is unique to this pathway in the MetaCyc database
	Enzyme present by hole filler. An enzyme for this reaction has been identified in this organism by the Pathway Hole Filler
	Orphan reaction. No sequenced enzyme from any domain of life is known for this reaction
	Key reaction. The reaction has been designated a key reaction of this pathway
	Spontaneous/other. Used for spontaneous reactions, and for lines that do not denote reactions (e.g., denoting repetition in polymerization pathways)

Pathway Summary Statistics

Fraction of genes devoted to metabolism	3251 of 20979 (15%)
Base pathways	367
Total reactions in the base pathways	1803
Base pathway reactions that are pathway holes	403 (22%)
Base pathway reactions that are not pathway holes	1400 (78%)

Metabolite Activation/Inactivation/Interconversion:Metabolite Activation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
long-chain fatty acid activation		na	1	1	0	(none)	0 of 0	yes
sulfate activation for sulfonation		na	2	2	0	(none)	0 of 0	yes

Biosynthesis:Amino Acid Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
diphthamide biosynthesis		na	3	2	0	(none)	0 of 0	NO
glutamine biosynthesis		na	1	1	0	(none)	0 of 0	yes
glycine biosynthesis		na	1	1	0	(none)	0 of 0	yes
glycine/serine biosynthesis		na	1	1	0	(none)	0 of 0	yes
hypusine biosynthesis		na	5	5	0	(none)	0 of 0	yes
L-alanine biosynthesis		na	1	1	0	(none)	0 of 0	yes
L-asparagine biosynthesis		na	1	1	0	(none)	0 of 0	yes
L-aspartate biosynthesis		na	1	1	0	(none)	0 of 0	yes
L-cysteine biosynthesis III (from L-homocysteine)		na	2	2	0	(none)	0 of 0	yes
L-glutamate biosynthesis		na	1	1	1	GABA shunt	0 of 0	yes
L-methionine salvage from L-homocysteine		na	3	3	0	(none)	0 of 0	yes
L-proline biosynthesis		na	4	3	0	(none)	0 of 0	yes
L-selenocysteine biosynthesis		na	4	4	0	(none)	0 of 0	yes
L-serine biosynthesis		na	3	3	0	(none)	0 of 0	yes
L-tyrosine biosynthesis		na	1	1	0	(none)	0 of 0	yes
ornithine de novo biosynthesis		na	3	3	0	(none)	0 of 0	yes
protein citrullination		na	1	1	0	(none)	0 of 0	yes
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation		na	7	6	0	(none)	1 of 1	yes
uracil degradation I (reductive)		na	3	3	0	(none)	0 of 0	yes

Biosynthesis:Aminoacyl-tRNA Charging

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
glutaminyl-tRNAgln biosynthesis via transamidation		na	4	3	0	(none)	0 of 0	yes
tRNA charging		na	21	20	0	(none)	0 of 0	yes

Biosynthesis:Aromatic Compound Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
4-hydroxybenzoate biosynthesis		na	5	1	0	(none)	0 of 0	yes

Biosynthesis:Carbohydrate Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide		na	10	10	0	(none)	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide		na	11	11	2	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
alpha-dystroglycan glycosylation		na	7	7	0	(none)	0 of 0	yes
chondroitin biosynthesis		na	3	3	0	(none)	0 of 0	yes
chondroitin sulfate biosynthesis		na	4	4	0	(none)	0 of 0	yes
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis		na	4	1	0	(none)	0 of 1	yes
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)		na	5	5	0	(none)	3 of 3	yes
complex N-linked glycan biosynthesis (vertebrates)		na	10	10	0	(none)	0 of 0	yes
dermatan sulfate biosynthesis		na	6	4	0	(none)	0 of 0	yes
erythritol biosynthesis II		na	2	1	0	(none)	0 of 0	yes
GDP-glucose biosynthesis II		na	3	3	0	(none)	0 of 0	yes
GDP-L-fucose biosynthesis I (from GDP-D-mannose)		na	3	3	0	(none)	2 of 2	yes
GDP-L-fucose biosynthesis II (from L-fucose)		na	2	2	0	(none)	0 of 0	yes
GDP-mannose biosynthesis		na	4	4	0	(none)	0 of 0	yes
gluconeogenesis		na	12	12	0	(none)	0 of 0	yes
glycogen biosynthesis		na	4	4	0	(none)	1 of 1	yes
glycosaminoglycan-protein linkage region biosynthesis		na	4	4	0	(none)	0 of 0	yes
heparan sulfate biosynthesis		na	12	12	0	(none)	0 of 0	yes
human milk oligisaccharides biosynthesis		na	19	17	0	(none)	0 of 0	yes
i antigen and I antigen biosynthesis		na	6	5	5	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
mucin core 1 and core 2 O-glycosylation		na	5	5	0	(none)	0 of 0	yes
mucin core 3 and core 4 O-glycosylation		na	3	2	0	(none)	0 of 0	yes
protein N-glycosylation initial phase (eukaryotic)		na	19	16	0	(none)	0 of 0	yes
protein N-glycosylation processing phase (mammalian)		na	20	19	0	(none)	0 of 0	yes
protein O-mannosylation II (mammals, core M1 and core M2)		na	5	4	0	(none)	0 of 0	yes
protein O-mannosylation III (mammals, core M3)		na	5	5	0	(none)	0 of 0	yes
protein O-[N-acetyl]-glucosylation		na	2	2	0	(none)	0 of 0	yes
PRPP biosynthesis		na	1	1	0	(none)	0 of 0	yes
UDP-alpha-D-glucose biosynthesis I		na	2	2	0	(none)	0 of 0	yes
UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)		na	1	1	0	(none)	0 of 0	yes
UDP-N-acetyl-D-galactosamine biosynthesis I		na	1	1	0	(none)	0 of 0	yes
UDP-N-acetyl-D-galactosamine biosynthesis II		na	7	7	0	(none)	1 of 1	NO
UDP-N-acetyl-D-glucosamine biosynthesis II		na	6	6	0	(none)	0 of 0	yes

Biosynthesis:Carboxylic Acid Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
itaconate biosynthesis I		na	2	1	0	(none)	1 of 1	yes

Biosynthesis:Cofactor, Carrier, and Vitamin Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
cobalamin salvage (eukaryotic)		na	8	7	0	(none)	0 of 0	yes
coenzyme A biosynthesis II (eukaryotic)		na	4	4	0	(none)	1 of 1	yes
cytochrome c biogenesis		na	1	1	0	(none)	0 of 0	yes
flavin biosynthesis		na	2	2	0	(none)	0 of 0	yes
folate polyglutamylation		na	5	4	0	(none)	0 of 0	yes
folate transformations I		na	12	9	0	(none)	0 of 0	yes
heme a biosynthesis		na	4	3	0	(none)	2 of 2	yes
heme biosynthesis from uroporphyrinogen-III I		na	4	4	0	(none)	1 of 1	yes
lipoate biosynthesis and incorporation		na	3	3	0	(none)	0 of 0	yes
menaquinol-4 biosynthesis II		na	3	1	0	(none)	0 of 0	yes
molybdenum cofactor biosynthesis		na	3	2	0	(none)	1 of 1	yes
molybdopterin biosynthesis		na	6	5	0	(none)	0 of 0	yes
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde		na	4	3	0	(none)	0 of 0	yes
NAD phosphorylation and transhydrogenation		na	2	2	0	(none)	0 of 0	yes
NAD salvage		na	2	2	0	(none)	1 of 1	yes
NAD salvage pathway IV (from nicotinamide riboside)		na	2	2	0	(none)	0 of 0	yes
pyridoxal 5'-phosphate salvage		na	5	5	0	(none)	0 of 0	yes
retinoate biosynthesis I		na	4	4	0	(none)	0 of 0	yes
retinoate biosynthesis II		na	3	3	0	(none)	0 of 0	yes
retinol biosynthesis		na	7	7	0	(none)	0 of 0	yes
S-adenosyl-L-methionine biosynthesis		na	1	1	0	(none)	0 of 0	NO
tetrahydrobiopterin de novo biosynthesis		na	4	4	0	(none)	0 of 0	yes
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate		na	2	2	0	(none)	0 of 0	yes
tetrahydropteridine recycling		na	2	2	0	(none)	0 of 0	yes
the visual cycle I (vertebrates)		na	12	8	0	(none)	0 of 0	yes
thiamine salvage III		na	1	1	0	(none)	0 of 0	yes
thio-molybdenum cofactor biosynthesis		na	1	1	0	(none)	0 of 0	yes
ubiquinol-10 biosynthesis (late decarboxylation)		na	10	8	0	(none)	0 of 0	yes
vitamin D3 biosynthesis		na	4	2	0	(none)	1 of 1	yes
vitamin K-epoxide cycle		na	4	4	0	(none)	0 of 0	yes
[2Fe-2S] iron-sulfur cluster biosynthesis		na	10	1	0	(none)	0 of 0	yes

Biosynthesis:Cyclitol Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)		na	5	5	0	(none)	1 of 1	yes
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)		na	5	5	0	(none)	1 of 1	NO
D-myo-inositol (1,3,4)-trisphosphate biosynthesis		na	3	3	0	(none)	0 of 0	yes
D-myo-inositol (1,4,5)-trisphosphate biosynthesis		na	5	5	0	(none)	0 of 0	yes
D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis		na	4	4	0	(none)	1 of 1	yes
D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis		na	4	4	0	(none)	1 of 1	yes
D-myo-inositol-5-phosphate metabolism		na	4	4	0	(none)	0 of 0	yes
inositol diphosphates biosynthesis		na	9	9	0	(none)	0 of 0	yes
myo-inositol biosynthesis		na	2	2	0	(none)	1 of 1	yes

Biosynthesis:Hormone, Neurotransmitter, and Signaling Molecule Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
11-oxyandrogens biosynthesis		na	20	19	0	(none)	0 of 0	yes
androgen biosynthesis		na	6	6	0	(none)	0 of 0	yes
C20 prostanoid biosynthesis		na	17	11	0	(none)	0 of 0	yes
catecholamine biosynthesis		na	4	4	0	(none)	0 of 0	yes
estradiol biosynthesis I (via estrone)		na	4	4	0	(none)	0 of 0	yes
estradiol biosynthesis II		na	3	3	0	(none)	0 of 0	yes
glucocorticoid biosynthesis		na	4	3	0	(none)	0 of 0	yes
leukotriene biosynthesis		na	6	6	0	(none)	0 of 0	yes
mineralocorticoid biosynthesis		na	5	4	0	(none)	0 of 0	yes
pregnenolone biosynthesis		na	3	3	0	(none)	0 of 0	yes
progesterone biosynthesis		na	2	2	0	(none)	0 of 0	yes
serotonin and melatonin biosynthesis		na	4	4	0	(none)	0 of 0	yes
thyroid hormone biosynthesis		na	6	5	0	(none)	4 of 4	yes
vitamin D3 biosynthesis		na	4	2	0	(none)	1 of 1	yes

Biosynthesis:Fatty Acid and Lipid Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)		na	5	4	0	(none)	1 of 1	yes
3-phosphoinositide biosynthesis		na	8	8	0	(none)	0 of 0	yes
acyl-CoA hydrolysis		na	1	1	0	(none)	0 of 0	yes
acylceramide biosynthesis and processing		na	8	7	0	(none)	0 of 0	yes
allopregnanolone biosynthesis		na	2	2	0	(none)	0 of 0	yes
anandamide biosynthesis I		na	12	9	0	(none)	3 of 3	yes
anandamide biosynthesis II		na	8	3	0	(none)	0 of 0	yes
arachidonate biosynthesis IV (8-detaturase)		na	7	2	0	(none)	0 of 1	yes
arachidonate biosynthesis V (8-detaturase, mammals)		na	6	4	1	arachidonate biosynthesis III (6-desaturase, mammals)	2 of 2	yes
arachidonate metabolites biosynthesis		na	74	32	0	(none)	0 of 0	yes
bile acid biosynthesis, neutral pathway		na	29	19	0	(none)	1 of 1	yes
cardenolide biosynthesis		na	10	1	0	(none)	0 of 0	NO
cardiolipin biosynthesis		na	3	3	0	(none)	0 of 0	yes
CDP-diacylglycerol biosynthesis		na	4	3	0	(none)	0 of 0	yes
ceramide de novo biosynthesis		na	4	4	0	(none)	0 of 0	yes
D-myo-inositol-5-phosphate metabolism		na	4	4	0	(none)	0 of 0	yes
di-homo-gamma-linolenate metabolites biosynthesis		na	16	1	0	(none)	0 of 0	yes
diacylglycerol and triacylglycerol biosynthesis		na	7	4	0	(none)	0 of 0	yes
docosahexaenoate biosynthesis III (6-desaturase, mammals)		na	14	7	0	(none)	0 of 0	yes
docosahexaenoate biosynthesis IV (4-desaturase, mammals)		na	6	3	0	(none)	1 of 1	yes
docosahexaenoate metabolites biosynthesis		na	31	16	0	(none)	0 of 0	yes
dolichol and dolichyl phosphate biosynthesis		na	6	5	0	(none)	1 of 1	yes
epoxysqualene biosynthesis		na	3	3	0	(none)	0 of 0	yes
fatty acid biosynthesis initiation (animals and fungi, cytoplasm)		na	3	3	0	(none)	0 of 0	yes
fatty acid biosynthesis initiation (mitochondria)		na	4	3	0	(none)	1 of 1	yes
gala-series glycosphingolipids biosynthesis		na	5	4	0	(none)	0 of 0	yes
gamma-linolenate biosynthesis		na	2	2	0	(none)	1 of 1	yes
ganglio-series glycosphingolipids biosynthesis		na	22	22	0	(none)	0 of 0	yes
globo-series glycosphingolipids biosynthesis		na	8	8	0	(none)	0 of 0	yes
icosapentaenoate biosynthesis II (6-desaturase, mammals)		na	7	4	0	(none)	0 of 0	yes
icosapentaenoate biosynthesis III (8-desaturase, mammals)		na	7	4	0	(none)	1 of 1	yes
icosapentaenoate metabolites biosynthesis		na	35	4	0	(none)	0 of 0	yes
lacto-series glycosphingolipids biosynthesis		na	7	7	0	(none)	0 of 0	yes
lanosterol biosynthesis		na	1	1	0	(none)	0 of 0	yes
linoleate metabolites biosynthesis		na	14	3	0	(none)	0 of 0	yes
long-chain fatty acid activation		na	1	1	0	(none)	0 of 0	yes
myristate biosynthesis (mitochondria)		na	25	25	0	(none)	0 of 0	yes
neolacto-series glycosphingolipids biosynthesis		na	12	12	0	(none)	0 of 0	yes
oleate biosynthesis		na	2	2	0	(none)	0 of 0	yes
palmitate biosynthesis (cytoplasm)		na	31	1	0	(none)	0 of 0	yes
phosphatidylcholine biosynthesis		na	3	3	0	(none)	0 of 0	yes
phosphatidylethanolamine biosynthesis II		na	4	3	0	(none)	1 of 1	yes
phosphatidylethanolamine biosynthesis III		na	1	1	0	(none)	0 of 0	yes
phosphatidylserine biosynthesis I		na	1	1	0	(none)	0 of 0	yes
phosphatidylserine biosynthesis II		na	1	1	0	(none)	0 of 0	yes
plasmalogen biosynthesis		na	16	15	0	(none)	1 of 1	yes
sphingomyelin metabolism		na	3	3	3	sphingolipid biosynthesis (mammals)	0 of 0	yes
stearate biosynthesis		na	6	5	0	(none)	1 of 1	yes
ultra-long-chain fatty acid biosynthesis		na	20	20	0	(none)	0 of 0	yes
very long chain fatty acid biosynthesis II		na	16	14	0	(none)	0 of 0	yes
zymosterol biosynthesis		na	8	8	5	cholesterol biosynthesis I	0 of 0	yes

Biosynthesis:Metabolic Regulator Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
carnosine biosynthesis		na	1	1	0	(none)	0 of 0	yes
citrulline-nitric oxide cycle		na	3	3	0	(none)	0 of 0	yes
creatine-phosphate biosynthesis		na	1	1	0	(none)	0 of 0	yes
fructose 2,6-bisphosphate biosynthesis		na	2	2	0	(none)	0 of 0	yes
homocarnosine biosynthesis		na	1	1	0	(none)	0 of 0	yes
L-carnitine biosynthesis		na	4	4	0	(none)	1 of 1	yes
Rapoport-Luebering glycolytic shunt		na	3	3	0	(none)	0 of 0	yes

Biosynthesis:Nucleoside and Nucleotide Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
5-aminoimidazole ribonucleotide biosynthesis		na	5	5	0	(none)	0 of 0	yes
adenine and adenosine salvage I		na	2	2	0	(none)	0 of 0	yes
adenine and adenosine salvage III		na	4	4	0	(none)	2 of 2	yes
adenine and adenosine salvage VI		na	1	1	0	(none)	0 of 0	yes
adenosine deoxyribonucleotides de novo biosynthesis		na	2	2	0	(none)	0 of 0	yes
adenosine ribonucleotides de novo biosynthesis		na	3	3	0	(none)	0 of 0	yes
CMP phosphorylation		na	2	2	0	(none)	0 of 0	yes
dTMP de novo biosynthesis (mitochondrial)		na	3	3	0	(none)	0 of 0	yes
guanine and guanosine salvage		na	2	2	0	(none)	0 of 0	yes
guanosine deoxyribonucleotides de novo biosynthesis		na	2	2	0	(none)	0 of 0	yes
guanosine ribonucleotides de novo biosynthesis		na	4	4	0	(none)	0 of 0	yes
inosine-5'-phosphate biosynthesis		na	5	5	0	(none)	1 of 1	yes
purine deoxyribonucleosides salvage		na	6	6	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleosides salvage		na	5	5	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotide phosphorylation		na	4	4	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotides biosynthesis from CTP		na	8	8	0	(none)	1 of 1	yes
pyrimidine deoxyribonucleotides de novo biosynthesis		na	9	9	0	(none)	1 of 1	yes
pyrimidine ribonucleosides salvage I		na	3	2	0	(none)	1 of 1	yes
UMP biosynthesis		na	6	6	0	(none)	1 of 1	yes
UTP and CTP de novo biosynthesis		na	3	3	0	(none)	0 of 0	yes

Biosynthesis:Other Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ascorbate recycling (cytosolic)		na	6	1	0	(none)	1 of 2	yes
creatine biosynthesis		na	2	2	0	(none)	2 of 2	yes
glutathione biosynthesis		na	2	2	0	(none)	0 of 0	yes
glutathione-glutaredoxin redox reactions		na	2	1	0	(none)	0 of 0	yes
glutathione-peroxide redox reactions		na	3	3	1	reactive oxygen species degradation	0 of 0	yes
L-dopa and L-dopachrome biosynthesis		na	3	1	0	(none)	0 of 0	yes
ophthalmate biosynthesis		na	3	3	0	(none)	0 of 0	yes
thioredoxin pathway		na	2	1	0	(none)	0 of 0	yes

Biosynthesis:Amide, Amidine, Amine, and Polyamine Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
creatine-phosphate biosynthesis		na	1	1	0	(none)	0 of 0	yes
histamine biosynthesis		na	1	1	0	(none)	0 of 0	yes
putrescine biosynthesis I		na	2	2	0	(none)	0 of 0	yes
putrescine biosynthesis III		na	2	2	0	(none)	0 of 0	yes
spermidine biosynthesis		na	2	2	0	(none)	0 of 0	yes
spermine biosynthesis		na	2	2	0	(none)	1 of 1	yes

Biosynthesis:Polyprenyl Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
geranylgeranyl diphosphate biosynthesis		na	1	1	0	(none)	0 of 0	yes
trans, trans-farnesyl diphosphate biosynthesis		na	2	2	0	(none)	1 of 1	yes

Biosynthesis:Secondary Metabolite Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
(S)-reticuline biosynthesis		na	7	1	0	(none)	0 of 0	yes
2-arachidonoylglycerol biosynthesis		na	7	6	0	(none)	0 of 0	yes
15-epi-lipoxin biosynthesis		na	5	3	0	(none)	0 of 0	yes
aspirin triggered resolvin D biosynthesis		na	10	5	0	(none)	0 of 0	yes
aspirin triggered resolvin E biosynthesis		na	6	4	0	(none)	0 of 0	yes
epoxysqualene biosynthesis		na	3	3	0	(none)	0 of 0	yes
eumelanin biosynthesis		na	6	3	0	(none)	0 of 0	yes
lipoxin biosynthesis		na	11	8	0	(none)	0 of 0	yes
maresin biosynthesis		na	5	3	0	(none)	0 of 0	yes
mevalonate pathway		na	7	7	0	(none)	2 of 2	yes
palmitoyl ethanolamide biosynthesis		na	6	2	0	(none)	1 of 1	yes
peptido-conjugates in tissue regeneration biosynthesis		na	17	16	0	(none)	0 of 0	yes
protectin biosynthesis		na	6	4	0	(none)	0 of 0	yes
resolvin D biosynthesis		na	11	7	0	(none)	0 of 0	yes
taurine biosynthesis I		na	3	3	0	(none)	0 of 0	yes
taurine biosynthesis II		na	4	3	0	(none)	0 of 0	yes

Biosynthesis:Tetrapyrrole Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
cytochrome c biogenesis		na	1	1	0	(none)	0 of 0	yes
heme a biosynthesis		na	4	3	0	(none)	2 of 2	yes
heme biosynthesis from uroporphyrinogen-III I		na	4	4	0	(none)	1 of 1	yes
tetrapyrrole biosynthesis		na	4	4	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Alcohol Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ethanol degradation II		na	3	3	0	(none)	1 of 1	yes
ethanol degradation III		na	3	3	0	(none)	1 of 1	yes
ethanol degradation IV		na	3	3	0	(none)	1 of 1	yes
glycerol degradation		na	3	1	0	(none)	0 of 0	yes
phytol degradation		na	4	2	0	(none)	1 of 1	yes
sorbitol degradation I		na	3	1	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Aldehyde Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
methylglyoxal degradation I		na	3	2	0	(none)	1 of 2	yes
methylglyoxal degradation III		na	2	2	0	(none)	0 of 0	yes
methylglyoxal degradation VI		na	4	1	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Amide, Amidine, Amine, and Polyamine Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
4-aminobutanoate degradation I		na	2	2	2	GABA shunt	0 of 0	yes
choline degradation		na	2	2	0	(none)	0 of 0	yes
dopamine degradation		na	5	5	0	(none)	0 of 0	yes
glycine betaine degradation II (mammalian)		na	4	3	0	(none)	0 of 0	yes
histamine degradation		na	3	2	0	(none)	1 of 1	yes
N-acetylglucosamine degradation I		na	2	2	0	(none)	0 of 0	yes
phenylethylamine degradation I		na	2	2	0	(none)	1 of 1	yes
putrescine degradation III		na	4	3	0	(none)	0 of 0	yes
spermine and spermidine degradation I		na	5	5	0	(none)	2 of 2	yes

Degradation/Utilization/Assimilation:Amino Acid Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
beta-alanine degradation		na	2	2	0	(none)	0 of 0	yes
creatine biosynthesis		na	2	2	0	(none)	2 of 2	yes
glycine cleavage		na	3	3	0	(none)	1 of 1	yes
L-alanine degradation		na	1	1	0	(none)	0 of 0	yes
L-asparagine degradation I		na	1	1	0	(none)	0 of 0	yes
L-aspartate degradation I		na	1	1	0	(none)	0 of 0	yes
L-cysteine biosynthesis III (from L-homocysteine)		na	2	2	0	(none)	0 of 0	yes
L-cysteine degradation I		na	3	2	0	(none)	0 of 0	yes
L-cysteine degradation III		na	2	2	0	(none)	0 of 0	yes
L-dopa degradation		na	4	1	0	(none)	1 of 2	yes
L-glutamate degradation (via 4-aminobutanoate)		na	1	1	1	GABA shunt	0 of 0	yes
L-glutamine degradation		na	1	1	0	(none)	0 of 0	yes
L-histidine degradation		na	6	6	0	(none)	0 of 0	yes
L-isoleucine degradation		na	6	6	0	(none)	0 of 0	yes
L-leucine degradation		na	6	6	0	(none)	1 of 1	yes
L-lysine degradation (pipecolate pathway)		na	9	7	0	(none)	0 of 0	yes
L-lysine degradation (saccharopine pathway)		na	5	5	0	(none)	0 of 0	yes
L-methionine degradation		na	3	2	0	(none)	0 of 0	yes
L-phenylalanine degradation I (aerobic)		na	1	1	0	(none)	0 of 0	yes
L-proline degradation		na	3	2	0	(none)	1 of 1	yes
L-serine degradation		na	3	1	0	(none)	0 of 0	yes
L-threonine degradation		na	2	2	1	2-oxobutanoate degradation	0 of 0	yes
L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde		na	5	5	5	L-tryptophan degradation XI (mammalian, via kynurenine)	0 of 0	yes
L-tryptophan degradation via tryptamine		na	4	4	0	(none)	3 of 3	yes
L-tyrosine degradation		na	5	5	0	(none)	0 of 0	yes
L-valine degradation		na	8	8	0	(none)	0 of 0	yes
trans-4-hydroxy-L-proline degradation		na	5	4	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Aromatic Compound Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
phenylethylamine degradation I		na	2	2	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:C1 Compound Utilization and Assimilation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
formaldehyde oxidation II (glutathione-dependent)		na	3	2	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:Carbohydrate Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2'-deoxy-alpha-D-ribose 1-phosphate degradation		na	3	3	0	(none)	0 of 0	yes
chondroitin sulfate degradation (metazoa)		na	1	1	0	(none)	0 of 0	yes
D-galactose degradation V (Leloir pathway)		na	5	5	0	(none)	0 of 0	yes
D-glucuronate degradation		na	5	3	0	(none)	0 of 0	yes
D-mannose degradation		na	1	1	0	(none)	0 of 0	yes
glycerol degradation		na	3	1	0	(none)	0 of 0	yes
glycogenolysis		na	6	5	0	(none)	0 of 0	yes
lactose degradation III		na	1	1	0	(none)	0 of 0	yes
N-acetylglucosamine degradation I		na	2	2	0	(none)	0 of 0	yes
sorbitol degradation I		na	3	1	0	(none)	0 of 0	yes
sucrose degradation		na	5	5	0	(none)	0 of 0	yes
trehalose degradation		na	2	2	0	(none)	1 of 1	NO

Degradation/Utilization/Assimilation:Carboxylic Acid Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA		na	5	3	0	(none)	0 of 0	yes
acetate conversion to acetyl-CoA		na	1	1	0	(none)	0 of 0	yes
D-glucuronate degradation		na	5	3	0	(none)	0 of 0	yes
glutaryl-CoA degradation		na	5	5	0	(none)	0 of 0	yes
propanoyl CoA degradation I		na	3	3	0	(none)	0 of 0	yes
pyruvate decarboxylation to acetyl CoA		na	3	3	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:Cofactor, Carrier, and Vitamin Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
alpha-tocopherol degradation		na	3	1	0	(none)	1 of 1	yes

Degradation/Utilization/Assimilation:Cyclitol Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
D-myo-inositol (1,4,5)-trisphosphate degradation		na	3	3	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Fatty Acid and Lipid Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-methyl-branched fatty acid beta-oxidation		na	14	8	0	(none)	0 of 0	yes
3-phosphoinositide degradation		na	9	8	0	(none)	0 of 0	yes
anandamide degradation		na	1	1	0	(none)	0 of 0	yes
anandamide lipoxygenation		na	6	3	0	(none)	0 of 0	yes
fatty acid alpha-oxidation		na	6	5	0	(none)	2 of 2	yes
fatty acid alpha-oxidation III		na	7	6	0	(none)	1 of 1	yes
fatty acid beta-oxidation		na	7	5	0	(none)	0 of 0	yes
fatty acid beta-oxidation (peroxisome)		na	7	7	0	(none)	1 of 1	yes
fatty acid beta-oxidation (unsaturated, odd number)		na	1	1	0	(none)	0 of 0	yes
mitochondrial L-carnitine shuttle		na	3	2	0	(none)	1 of 1	yes
phospholipases		na	5	5	0	(none)	0 of 0	yes
plasmalogen degradation		na	8	8	0	(none)	0 of 0	yes
sphingosine and sphingosine-1-phosphate metabolism		na	10	6	0	(none)	0 of 0	yes
triacylglycerol degradation		na	3	3	0	(none)	1 of 1	yes
valproate beta-oxidation		na	9	5	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Hormone, Neurotransmitter, and Signaling Molecule Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
melatonin degradation I		na	5	5	0	(none)	2 of 2	yes
melatonin degradation II		na	4	1	0	(none)	0 of 1	yes
melatonin degradation III		na	2	1	0	(none)	0 of 0	yes
noradrenaline and adrenaline degradation		na	13	12	0	(none)	3 of 4	yes
serotonin degradation		na	7	6	0	(none)	1 of 1	yes
thyroid hormone metabolism I (via deiodination)		na	12	9	0	(none)	2 of 2	yes
thyroid hormone metabolism II (via conjugation and/or degradation)		na	15	11	0	(none)	6 of 6	yes
thyronamine and iodothyronamine metabolism		na	12	8	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Inorganic Nutrient Metabolism

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
glutamine biosynthesis		na	1	1	0	(none)	0 of 0	yes
hydrogen sulfide biosynthesis II (mammalian)		na	6	6	0	(none)	0 of 0	yes
L-cysteine degradation III		na	2	2	0	(none)	0 of 0	yes
sulfate activation for sulfonation		na	2	2	0	(none)	0 of 0	yes
sulfide oxidation IV (metazoa)		na	5	4	0	(none)	0 of 0	yes
sulfite oxidation		na	1	1	0	(none)	0 of 0	yes
thiosulfate disproportionation IV (rhodanese)		na	1	1	0	(none)	0 of 0	yes
urea cycle		na	5	5	0	(none)	2 of 2	yes

Degradation/Utilization/Assimilation:Nucleoside and Nucleotide Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
adenosine nucleotides degradation		na	5	5	0	(none)	1 of 1	yes
guanosine nucleotides degradation		na	4	4	0	(none)	0 of 0	yes
inosine 5'-phosphate degradation		na	4	4	0	(none)	0 of 0	yes
purine deoxyribonucleosides degradation		na	3	3	0	(none)	0 of 0	yes
purine ribonucleosides degradation to ribose-1-phosphate		na	6	6	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleosides degradation		na	3	3	0	(none)	0 of 0	yes
pyrimidine ribonucleosides degradation		na	2	2	0	(none)	1 of 1	yes
S-methyl-5'-thioadenosine degradation		na	1	1	0	(none)	0 of 0	yes
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation		na	7	6	0	(none)	1 of 1	yes
thymine degradation		na	3	3	0	(none)	0 of 0	yes
uracil degradation I (reductive)		na	3	3	0	(none)	0 of 0	yes
UTP and CTP dephosphorylation I		na	7	7	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Degradation/Utilization/Assimilation - Other

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
acetone degradation I (to methylglyoxal)		na	3	1	0	(none)	0 of 0	yes
acetone degradation III (to propane-1,2-diol)		na	2	2	0	(none)	0 of 0	yes
bupropion degradation		na	5	1	0	(none)	0 of 0	yes
carbon disulfide oxidation III (metazoa)		na	5	1	0	(none)	0 of 0	yes
glutathione-mediated detoxification I		na	8	5	0	(none)	0 of 0	yes
heme degradation I		na	6	6	0	(none)	0 of 0	yes
nicotine degradation IV		na	16	5	0	(none)	0 of 0	yes
nicotine degradation V		na	18	8	0	(none)	0 of 0	yes

Degradation/Utilization/Assimilation:Polymeric Compound Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
chondroitin sulfate degradation (metazoa)		na	1	1	0	(none)	0 of 0	yes
glycogenolysis		na	6	5	0	(none)	0 of 0	yes

Detoxification:8-oxo-GTP and 8-oxo-dGTP Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
oxidized GTP and dGTP detoxification		na	4	1	0	(none)	0 of 0	yes

Detoxification:Acid Resistance

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
L-glutamate degradation (via 4-aminobutanoate)		na	1	1	1	GABA shunt	0 of 0	yes

Detoxification:Arsenic Compound Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
arsenic detoxification (mammals)		na	17	8	0	(none)	1 of 3	yes

Detoxification:Methylglyoxal Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
methylglyoxal degradation I		na	3	2	0	(none)	1 of 2	yes
methylglyoxal degradation III		na	2	2	0	(none)	0 of 0	yes
methylglyoxal degradation VI		na	4	1	0	(none)	0 of 0	yes

Detoxification:Reactive Oxygen Species Degradation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
superoxide radicals degradation		na	2	2	2	reactive oxygen species degradation	0 of 0	yes

Detoxification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
4-hydroxy-2-nonenal detoxification		na	4	4	0	(none)	0 of 0	yes
glutathione-mediated detoxification I		na	8	5	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Acetyl-CoA Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
acetyl-CoA biosynthesis from citrate		na	1	1	0	(none)	0 of 0	yes
ketolysis		na	3	3	0	(none)	0 of 0	yes
pyruvate decarboxylation to acetyl CoA		na	3	3	0	(none)	1 of 1	yes

Generation of Precursor Metabolites and Energy:Electron Transfer Chains

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
aerobic respiration I (cytochrome c)		na	4	4	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Fermentation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
pyruvate fermentation to (S)-lactate		na	1	1	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Glycolysis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
glycolysis		na	10	10	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Pentose Phosphate Pathways

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
pentose phosphate pathway (non-oxidative branch)		na	5	5	0	(none)	1 of 1	yes
pentose phosphate pathway (oxidative branch)		na	3	3	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:Respiration

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-oxoisovalerate decarboxylation to isobutanoyl-CoA		na	3	3	0	(none)	1 of 1	yes
aerobic respiration I (cytochrome c)		na	4	4	0	(none)	0 of 0	yes

Generation of Precursor Metabolites and Energy:TCA cycle

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
TCA cycle		na	10	10	0	(none)	2 of 2	yes

Generation of Precursor Metabolites and Energy

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-oxoglutarate decarboxylation to succinyl-CoA		na	3	3	0	(none)	1 of 1	yes
ATP biosynthesis		na	1	1	0	(none)	0 of 0	yes
biotin-carboxyl carrier protein assembly		na	4	3	0	(none)	0 of 0	yes
glycerol-3-phosphate shuttle		na	2	1	0	(none)	0 of 0	yes
ketogenesis		na	5	5	0	(none)	0 of 0	yes
malate-aspartate shuttle		na	2	2	0	(none)	0 of 0	yes
NADH repair		na	4	4	0	(none)	1 of 1	yes

Glycan Pathways:Polysaccharide Biosynthesis

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
chondroitin biosynthesis		na	3	3	0	(none)	0 of 0	yes
chondroitin sulfate biosynthesis		na	4	4	0	(none)	0 of 0	yes
dermatan sulfate biosynthesis		na	6	4	0	(none)	0 of 0	yes
glycogen biosynthesis		na	4	4	0	(none)	1 of 1	yes
heparan sulfate biosynthesis		na	12	12	0	(none)	0 of 0	yes

Glycan Pathways:Protein Glycosylation

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide		na	10	10	0	(none)	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide		na	11	11	2	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
alpha-dystroglycan glycosylation		na	7	7	0	(none)	0 of 0	yes
complex N-linked glycan biosynthesis (vertebrates)		na	10	10	0	(none)	0 of 0	yes
glycosaminoglycan-protein linkage region biosynthesis		na	4	4	0	(none)	0 of 0	yes
i antigen and I antigen biosynthesis		na	6	5	5	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
mucin core 1 and core 2 O-glycosylation		na	5	5	0	(none)	0 of 0	yes
mucin core 3 and core 4 O-glycosylation		na	3	2	0	(none)	0 of 0	yes
protein N-glycosylation initial phase (eukaryotic)		na	19	16	0	(none)	0 of 0	yes
protein N-glycosylation processing phase (mammalian)		na	20	19	0	(none)	0 of 0	yes
protein O-mannosylation II (mammals, core M1 and core M2)		na	5	4	0	(none)	0 of 0	yes
protein O-mannosylation III (mammals, core M3)		na	5	5	0	(none)	0 of 0	yes
protein O-[N-acetyl]-glucosylation		na	2	2	0	(none)	0 of 0	yes

Glycan Pathways

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
chondroitin sulfate degradation (metazoa)		na	1	1	0	(none)	0 of 0	yes
glycogenolysis		na	6	5	0	(none)	0 of 0	yes
human milk oligisaccharides biosynthesis		na	19	17	0	(none)	0 of 0	yes

Macromolecule Modification:Nucleic Acid Processing

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
7-(3-amino-3-carboxypropyl)-wyosine biosynthesis		na	4	3	0	(none)	0 of 0	NO
mRNA capping I		na	3	3	0	(none)	0 of 0	yes
N1-methyl-N3-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis		na	3	3	0	(none)	0 of 0	yes
queuosine biosynthesis II (queuine salvage)		na	1	1	0	(none)	0 of 0	yes
tRNA splicing II		na	2	2	0	(none)	1 of 1	yes
tRNA-uridine 2-thiolation (cytoplasmic)		na	8	7	0	(none)	0 of 0	yes
tRNA-uridine 2-thiolation (mammalian mitochondria)		na	4	4	0	(none)	0 of 0	yes

Macromolecule Modification:Protein Modification

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
5-oxo-L-proline metabolism		na	6	4	1	γ-glutamyl cycle	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide		na	10	10	0	(none)	0 of 0	yes
ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide		na	11	11	2	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
acyl carrier protein activation		na	1	1	0	(none)	0 of 0	yes
alpha-dystroglycan glycosylation		na	7	7	0	(none)	0 of 0	yes
Arg/N-end rule pathway (eukaryotic)		na	14	11	0	(none)	0 of 0	yes
blood coagulation - tissue factor pathway		na	11	8	0	(none)	0 of 0	yes
complex N-linked glycan biosynthesis (vertebrates)		na	10	10	0	(none)	0 of 0	yes
cytochrome c biogenesis		na	1	1	0	(none)	0 of 0	yes
glycosaminoglycan-protein linkage region biosynthesis		na	4	4	0	(none)	0 of 0	yes
i antigen and I antigen biosynthesis		na	6	5	5	terminal O-glycans residues modification (via type 2 precursor disaccharide)	0 of 0	yes
mucin core 1 and core 2 O-glycosylation		na	5	5	0	(none)	0 of 0	yes
mucin core 3 and core 4 O-glycosylation		na	3	2	0	(none)	0 of 0	yes
procollagen hydroxylation and glycosylation		na	6	5	0	(none)	0 of 0	yes
protein N-glycosylation initial phase (eukaryotic)		na	19	16	0	(none)	0 of 0	yes
protein N-glycosylation processing phase (mammalian)		na	20	19	0	(none)	0 of 0	yes
protein NEDDylation		na	3	3	0	(none)	0 of 0	yes
protein O-mannosylation II (mammals, core M1 and core M2)		na	5	4	0	(none)	0 of 0	yes
protein O-mannosylation III (mammals, core M3)		na	5	5	0	(none)	0 of 0	yes
protein O-[N-acetyl]-glucosylation		na	2	2	0	(none)	0 of 0	yes
protein S-nitrosylation and denitrosylation		na	5	1	0	(none)	0 of 0	yes
protein ubiquitination		na	9	9	0	(none)	0 of 0	yes

Macromolecule Modification

Pathway

Pathway Glyph

Pathway Score

Total Rxns

Rxns Present in Homo sapiens

Rxns Present in Other Pwys

Other Pwys

Key Rxns Present

In Taxonomic Range?

Links

Metabolic Clusters

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
2-methyl-branched fatty acid beta-oxidation		na	14	8	0	(none)	0 of 0	yes
Arg/N-end rule pathway (eukaryotic)		na	14	11	0	(none)	0 of 0	yes
blood coagulation - tissue factor pathway		na	11	8	0	(none)	0 of 0	yes
hydrogen sulfide biosynthesis II (mammalian)		na	6	6	0	(none)	0 of 0	yes
oxidized GTP and dGTP detoxification		na	4	1	0	(none)	0 of 0	yes
phospholipases		na	5	5	0	(none)	0 of 0	yes
purine deoxyribonucleosides salvage		na	6	6	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotide phosphorylation		na	4	4	0	(none)	0 of 0	yes
pyrimidine deoxyribonucleotides biosynthesis from CTP		na	8	8	0	(none)	1 of 1	yes
pyrimidine deoxyribonucleotides de novo biosynthesis		na	9	9	0	(none)	1 of 1	yes
tRNA charging		na	21	20	0	(none)	0 of 0	yes

Signal transduction pathways

Pathway	Pathway Glyph	Pathway Score	Total Rxns	Rxns Present in Homo sapiens	Rxns Present in Other Pwys	Other Pwys	Key Rxns Present	In Taxonomic Range?	Links
BMP Signalling Pathway		na	17	2	0	(none)	0 of 0	yes
MAP kinase cascade		na	4	2	0	(none)	0 of 0	yes

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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
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