HumanCyc: Encyclopedia of Human Genes and Metabolism
HumanCyc provides an encyclopedic reference on human metabolic pathways.
It provides a zoomable human metabolic map diagram, and it has been used to generate a steady-state quantitative model of human metabolism.
HumanCyc is part of the larger BioCyc collection of thousands of Pathway/Genome Databases for sequenced genomes.
Click "change organism database" in the upper right corner to explore the available databases.
Subscriptions are now required to access HumanCyc. For more information on obtaining a subscription, click here. Why the transition to subscriptions?
Getting Started
New to HumanCyc? Typical usage includes:
- Search for a gene or pathway using the Quick Search box at the upper right, or use the Search menu
- Analyze human metabolomics and gene-expression data
For more information on HumanCyc, see our article "Computational prediction of human metabolic pathways from the complete human genome" in Genome Biology.
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Tools
HumanCyc provides tools for querying, visualizing, and analyzing the underlying database, and for analyzing omics data:
- Multiple pathway-analysis methods are available for omics and multi-omics datasets including painting data onto pathway diagrams and the metabolic-map diagram
- Store groups of genes and pathways in your account as SmartTables; share, analyze, transform those groups
- Search for paths in the metabolic network using the Metabolism → Metabolic Route Search tool
HumanCyc Curation
Curation primarily affects information on pathways and corresponding enzyme pages. HumanCyc is a partially curated database and is a work in progress; it is incomplete in many respects, and may contain errors.
HumanCyc contains few signaling pathways. It is not yet compartmentalized nor tissue-specific.
For information regarding most recently curated pathways see the Release Notes.
Video Tutorials
HumanCyc is built on the same software platform as Biocyc: Pathway Tools. The BioCyc webinar series introduces users to the basic and advanced features of the Pathway Tools software in the context of BioCyc. A complete list of videos in additional download formats are available on the Video and Podcast page.
This video introduces the BioCyc.org site and the BioCyc collection of hundreds of Pathway/Genome Databases and covers:
- BioCyc site contents, including EcoCyc, MetaCyc, and our extensive database collection
- How to search, browse, and find what you need in the BioCyc collection
- How we represent metabolism, transcription, and all their parts