HumanCyc: Encyclopedia of Human Genes and Metabolism

Subscriptions are now required to access HumanCyc. For more information on obtaining a subscription, click here. Why the transition to subscriptions?

HumanCyc provides an encyclopedic reference on human metabolic pathways. It provides a zoomable human metabolic map diagram, and it has been used to generate a steady-state quantitative model of human metabolism.

Getting Started

New to HumanCyc? Typical usage includes:

• Search for a gene or pathway using the Quick Search box at the upper right, or use the Search menu
• Analyze human metabolomics and gene-expression data

For more information on HumanCyc, see our article "Computational prediction of human metabolic pathways from the complete human genome" in Genome Biology.

Tools

HumanCyc provides tools for querying, visualizing, and analyzing the underlying database, and for analyzing omics data:

• Multiple pathway-analysis methods are available for omics and multi-omics datasets including painting data onto pathway diagrams and the metabolic-map diagram
• Store groups of genes and pathways in your account as SmartTables; share, analyze, transform those groups
• Search for paths in the metabolic network using the Metabolism → Metabolic Route Search tool

HumanCyc Curation

Curation primarily affects information on pathways and corresponding enzyme pages. HumanCyc is a partially curated database and is a work in progress; it is incomplete in many respects, and may contain errors.

HumanCyc contains few signaling pathways. It is not yet compartmentalized nor tissue-specific.

For information regarding most recently curated pathways see the Release Notes.