HumanCyc: Encyclopedia of Homo sapiens Genes and Metabolism
HumanCyc is a multi-functional database:
- It provides an encyclopedic reference on human metabolic pathways
- It provides a computer-queryable database of human metabolic pathways
- It provides a zoomable human metabolic map diagram
- It has been used to generate a steady-state quantitative model of human metabolism
New to HumanCyc? Typical usage includes:
- Analyze human metabolomics and gene-expression data
- Search for a gene or pathway using the Quick Search, or use the Search menu for more options
For more information on HumanCyc, see our article "Computational prediction of human metabolic pathways from the complete human genome" in Genome Biology.User Guide >>
Heme, Not Just the Red Pigment in Blood.
Heme, an iron-containing porphyrin, functions as a prosthetic group in numerous proteins. These range from components of the electron transport chain to many enzymes. No wonder the biosynthesis of heme is highly conserved in evolution!Learn More
Navigate Metabolic Map for Pathways
The Cellular Overview enables you to browse through a zoomable metabolic map diagram that displays pathways according to groups based on biological function, or classes of metabolites produced/consumed.Learn More
Important Mammalian Pathways: The Urea Cycle
The urea cycle is responsible for mediating excretion of nitrogenous waste. It was the first metabolic pathway to be discovered, five years before the discovery of the TCA cycle. The cycle occurs across both the cytosol and the mitchondrion.Learn More
RouteSearch: Search for Paths through the Metabolic Network
Search for lowest-cost paths through the metabolic network of the selected organism. Or, design lowest-cost pathways to novel compounds by adding reactions from MetaCyc.Learn More
A Pathway Linked to Central Nervous System Disorders
The GABA shunt forms a closed loop in the CNS for conserving the supply of the excitatory neurotransmitter GABA. One of the enzymes of this pathway, 4-aminobutyrate aminotransferase is a target for the anti-epileptic drug vigabatrin.Learn More
Metabolomics Data Analysis
Multiple tools are available in this website for metabolomics data analysis.Learn More
The Truth about the Thanksgiving Turkey...
Of the 20 amino acids, at least 9 are essential. Essential L-tryptophan is required for serotonin, melatonin and niacin synthesis. Its requirement for NAD biosynthesis was discovered when humans stricken with pellagra recovered after the addition of tryptophan or niacin to their diets.Learn More
Gene Expression Data Analysis
Multiple tools are available in this website for analysis of gene expression data.Learn More
HumanCyc provides tools for navigating, visualizing, and analyzing the underlying databases, and for analyzing omics data:
- Display of individual metabolic pathways (for example, the TCA cycle), and full metabolic maps
- Multiple analysis methods for user-supplied omics and multi-omics datasets including painting onto metabolic maps, regulatory maps, and genome maps
- Store groups of genes and pathways in your account as Smart Tables; share, analyze, transform those groups
- Comparative analysis tools
Curation primarily affects information on pathways and corresponding enzyme pages. HumanCyc is a partially curated database and is a work in progress, incomplete in many respects, and may contain errors.
HumanCyc contains few signaling pathways. It is not yet compartmentalized nor tissue-specific.
For information regarding most recently curated pathways see the Release Notes.
HumanCyc is built on the same software platform as Biocyc: Pathway Tools. The BioCyc webinar series introduces users to the basic and advanced features of the Pathway Tools software in the context of BioCyc. A complete list of videos in additional download formats are available on the Video and Podcast page.
This video introduces the BioCyc.org site and the BioCyc collection of hundreds of Pathway/Genome Databases and covers:
- BioCyc site contents, including EcoCyc, MetaCyc, and our extensive database collection
- How to search, browse, and find what you need in the BioCyc collection
- How we represent metabolism, transcription, and all their parts